{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T23:10:09Z","timestamp":1749078609706,"version":"3.41.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010566","name":"Rome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Previous epidemiology studies from Malaysia on disorders of gut\u2013brain interaction (DGBI) have utilized variable criteria. Furthermore, the impact of DGBI on quality of life (QoL), healthcare utilization, diet, work productivity, and sleep in a multiethnic Asian setting like Malaysia remains underexplored. Here, we aimed to determine the epidemiology and impact of DGBI among multiethnic Malaysians based on the Rome IV criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>2072 Malaysian participants from the Rome Foundation Global Epidemiology Study (RFGES) with complete data on DGBI were included in the in\u2010depth analysis. We assessed the prevalence of DGBI diagnoses, psychological distress, QoL, healthcare utilization, dietary patterns, impact on sleep, work productivity, and activity impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of any DGBI in Malaysia was 19.3% (95% CI 17.6%\u201321.0%). The top three most prevalent DGBI diagnoses were functional constipation (5.1%; 95% CI 4.2%\u20136.1%), functional dyspepsia (3.4%; 95% CI 2.7%\u20134.3%), and functional diarrhea (1.6%; 95% CI 1.1%\u20132.2%). Participants with DGBI reported higher levels of psychological distress (somatization, anxiety, and depression), significantly higher healthcare utilization, and dietary change (low FODMAPs but higher Mediterranean\u2010based diet and probiotics). Furthermore, there was greater daytime sleepiness and higher proportions of presenteeism, overall work impairment, and activity impairment in individuals with DGBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The disease burden of DGBI is significant in Malaysia, with increased psychological distress, healthcare utilization, dietary change, greater daytime sleepiness, and greater overall work and activity impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16953","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T10:26:54Z","timestamp":1743762414000},"page":"1472-1484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology and Impact of Disorders of Gut\u2013Brain Interaction in Multiethnic Malaysia: An In\u2010Depth Analysis of Local Data From the Rome Foundation Global Epidemiology Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-2112","authenticated-orcid":false,"given":"Daniel\u00a0Martin","family":"Simadibrata","sequence":"first","affiliation":[{"name":"Department of Medicine, MetroHealth Medical Center Case Western Reserve University  Cleveland Ohio USA"},{"name":"Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira","family":"Lesmana","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6671-0929","authenticated-orcid":false,"given":"Thai\u00a0Hau","family":"Koo","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Malaysia"},{"name":"Gastrointestinal Function and Motility Unit Hospital USM  Kota Bharu Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hematram","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Mahsa University  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuck\u00a0Meng","family":"Chong","sequence":"additional","affiliation":[{"name":"Klinik Chong  Slim River Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamarul\u00a0Imran","family":"Musa","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kueh\u00a0Yee","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Universiti Sains Malaysia  Kota Bharu 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