{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:18:09Z","timestamp":1780568289985,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Small bowel (SB) video capsule endoscopy (VCE) is an established diagnostic tool for the investigation of SB pathologies. Despite clinical studies and a few meta\u2010analyses, an area of continuing controversy is the role of pre\u2010procedural bowel preparation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We compared the visibility and performance of VCE with and without purge preparation in the same patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Post hoc analysis of randomized control trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a post hoc analysis of the prospective randomized CURE\u2010CD Trial (Comprehensive individUalized pRoactive ThErapy of Crohn's Disease trial). Established Crohn's disease (CD) patients in clinical remission were enrolled and classified into two groups according to relapse risk assessment. All patients are followed up in our clinic and undergo laboratory tests every 3\u2009months and serial VCE studies every 6\u2009months. The first VCE is done after bowel preparation with a clear liquid diet, PEG, and laxative, whereas the subsequent VCEs, when disease is confined to SB only, are done after a day on clear liquid diet. The VCE visibility is rated (1\u20134 points) by a blind observer, unaware to the preparation regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients who underwent at least two VCEs, at baseline and after 6\u2009months were included. Visibility scores were similar in these two time points (3.15 vs. 3.10, <jats:italic>p<\/jats:italic>\u2009=\u20090.8). Among the low\u2010risk patients' group (<jats:italic>n<\/jats:italic>\u2009=\u200916) in whom the clinical parameters (CDAI, CRP, and fecal calprotectin) have not changed significantly during this period, Inflammatory scores assessed by the capsule Lewis score (LS) and PillCam\u2010CD score (PCDS) were similar (median LS 225 vs. 225, <jats:italic>p<\/jats:italic>\u2009=\u20090.87, median PCDS 4 vs. 2, <jats:italic>p<\/jats:italic>\u2009=\u20090.37).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The visibility and performance of SB VCE for monitoring Crohn's disease is not significantly influenced by purge preparation.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> Clinicatrials.gov identifier: NCT03555058.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16954","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T19:41:18Z","timestamp":1743795678000},"page":"1485-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Visibility and Performance of Small Bowel Video Capsule Endoscopy With and Without Pre\u2010Procedural Purge Preparation in the Same Patients"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-7924","authenticated-orcid":false,"given":"Reuma","family":"Margalit\u00a0Yehuda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sackler Medical School Tel Aviv University  Ramat Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6524-1644","authenticated-orcid":false,"given":"Yana","family":"Davidov","sequence":"additional","affiliation":[{"name":"Sackler Medical School Tel Aviv University  Ramat Aviv Israel"},{"name":"Liver Disease Center Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limor","family":"Selinger","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bella","family":"Ungar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sackler Medical School Tel Aviv University  Ramat Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Lahat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sackler Medical School Tel Aviv University  Ramat Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Yablecovitch","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sackler Medical School Tel Aviv University  Ramat Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Neuman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Kopylov","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sackler Medical School Tel Aviv University  Ramat Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shomron","family":"Ben\u00a0Horin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sackler Medical School Tel Aviv University  Ramat Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Eliakim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center  Tel Hashomer Israel"},{"name":"Sackler Medical School Tel Aviv University  Ramat Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For the Israeli IBD Research Nucleus (IIRN)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i46.6140"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(03)02862-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.09.031"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.012"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2006.01.020"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.747953"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328365b9d4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.63"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.1313"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2017.1359540"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2009.3.3.180"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)01879-6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32832b8d2f"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1500-2"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000159271.43233.45"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1693-z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490942"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.06.044"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255916"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2016.0012"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.07.028"},{"key":"e_1_2_11_23_1","first-page":"327","article-title":"Effect of Different Modalities of Purgative Preparation on the Diagnostic Yield of Small Bowel Capsule for the Exploration of Suspected Small Bowel Bleeding: A Multicenter Randomized Controlled Trial","volume":"2","author":"Rahmi G.","year":"2022","journal-title":"American Journal of Gastroenterology"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-125207"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.16954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T22:32:01Z","timestamp":1749076321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.16954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jgh.16954"],"URL":"https:\/\/doi.org\/10.1111\/jgh.16954","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,3]]},"assertion":[{"value":"2024-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}