{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:17:33Z","timestamp":1767907053163,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030680","name":"Fu Jen Catholic University Hospital","doi-asserted-by":"publisher","award":["Grants PL\u201020200800X to Lee FJ"],"award-info":[{"award-number":["Grants PL\u201020200800X to Lee FJ"]}],"id":[{"id":"10.13039\/100030680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030680","name":"Fu Jen Catholic University Hospital","doi-asserted-by":"publisher","award":["PL\u201020200800X"],"award-info":[{"award-number":["PL\u201020200800X"]}],"id":[{"id":"10.13039\/100030680","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>With rising rates of esophageal adenocarcinoma (EAC) in Western countries, Barrett's esophagus (BE) has become a growing concern. The increasing prevalence of chronic gastroesophageal reflux disease (GERD) in Taiwan suggests a potential rise in BE cases as well. A 2007 large\u2010scale study reported a BE prevalence of 1.06% in Taiwan. Our multicenter prospective study aims to evaluate the current prevalence of BE and identify key risk factors in this region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We assessed outpatients undergoing upper gastrointestinal endoscopy for various symptoms, obtaining biopsies from endoscopically suspected esophageal metaplasia (ESEM) at least 1\u2009cm above the gastroesophageal junction. Quadrant biopsies were taken every 2\u2009cm, with BE confirmed by histological evidence of specialized intestinal metaplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 8697 subjects, the prevalence of BE was 2.6%. GERD symptoms, erosive esophagitis (EE), and hiatal hernia (HH) were present in 52.5%, 27.3%, and 7.85% of subjects, respectively. Of 751 with ESEM, 228 were diagnosed with BE, predominantly short\u2010segment BE (78.1%). Multivariate analysis identified significant risk factors for BE: age\u2009&gt;\u200950 (OR\u2009=\u20091.59), male gender (OR\u2009=\u20092.27), alcohol consumption (OR\u2009=\u20091.70), GERD symptoms (OR\u2009=\u20091.45), EE (OR\u2009=\u20091.94), and HH (OR\u2009=\u20092.49) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of BE was identified as 2.6%, representing a significant increase compared with 2007. Significant risk factors include age more than 50, male gender, alcohol use, GERD symptoms, EE, and HH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16992","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T22:48:06Z","timestamp":1745966886000},"page":"1695-1702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased Prevalence of Barrett's Esophagus in Taiwan: A Prospective Multicenter Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4503-3255","authenticated-orcid":false,"given":"Fu\u2010Jen","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Fu Jen Catholic University Hospital  New Taipei City Taiwan"},{"name":"School of Medicine Fu Jen Catholic University College of Medicine  New Taipei City 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