{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:31:59Z","timestamp":1791045119321,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Colonoscopy is a widely used diagnostic and therapeutic procedure. The impact of frailty on outcomes of hospitalized older patients undergoing colonoscopy is unclear. This study aims to evaluate associations between frailty and outcomes of hospitalized older adults undergoing colonoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were extracted from the Nationwide Inpatient Sample (NIS), 2016\u20132020. Hospitalized patients \u2265\u200965\u2009years old who underwent colonoscopy were included. Frailty was assessed using a modified frailty index (mFI), and frail was defined as mFI \u2265\u20090.27. The primary outcomes were in\u2010hospital mortality, nonroutine discharge, prolonged length of stay (LOS) (\u2265\u200975th percentile), postprocedural dysrhythmia, and other postprocedural complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 142\u2009257 hospitalized older adults were included, with 29\u2009558 categorized as frail. The mean age was 77\u2009years, and 54% were males. Frail patients had significantly higher in\u2010hospital mortality (2.7% vs. 1.7%), nonroutine discharge (27.8% vs. 19.6%), prolonged LOS (33.9% vs. 24.2%), and postprocedural dysrhythmia (46.3% vs. 29.2%) compared to nonfrail patients (all, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After adjusting for covariates, frailty remained significantly associated with increased risks of in\u2010hospital mortality (odds ratio [OR]\u2009=\u20091.60), nonroutine discharge (OR\u2009=\u20091.62), prolonged LOS (OR\u2009=\u20091.62), and postprocedural dysrhythmia (OR\u2009=\u20092.12). Stratified analyses by sex and age obtained the same results across all subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Frailty is significantly associated with adverse outcomes in hospitalized older adults undergoing colonoscopy. These findings highlight the importance of increased periprocedural care for frail patients to improve clinical outcomes and optimize resource utilization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.16998","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T11:28:51Z","timestamp":1746703731000},"page":"1711-1718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Frailty on Care Burden of Hospitalized Older Adults Receiving Colonoscopy: A 2016\u20132020 Nationwide Inpatient Sample Analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"Chao\u2010Ling","family":"Cheng","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Wan Fang Hospital, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Jui","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Wan Fang Hospital, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0497-7566","authenticated-orcid":false,"given":"Shih\u2010Ping","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Wan Fang Hospital, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-020-00764-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-024-02087-x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2208375"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i2.190"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i26.2833"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528561"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101498"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/08982643211040706"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20200034"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100960"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17537"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5129-x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.01.021"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-8-24"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afad221"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2022.104667"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-023-02944-3"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-024-10965-x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.031736"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.09.008"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1575-3"},{"key":"e_1_2_11_23_1","first-page":"658","article-title":"Frailty, Periinterventional Complications and Outcome in Patients Undergoing Percutaneous Mitral and Tricuspid Valve Repair","volume":"113","author":"Sch\u00e4fer M.","year":"2024","journal-title":"Clinical Research in Cardiology"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2023-001193"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2023.05.004"},{"key":"e_1_2_11_26_1","volume-title":"StatPearls [Internet]","author":"Pfeifer C. 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