{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:10:08Z","timestamp":1751382608014,"version":"3.41.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["Intelligent & Sustainable Medical Electronics Research Fund"],"award-info":[{"award-number":["Intelligent & Sustainable Medical Electronics Research Fund"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Fecal incontinence severely deteriorates normal social function and quality of life. We investigated the relationship between short squeeze contractile integral (SSCI), endurance squeeze contractile integral (ESCI) of high\u2010resolution anorectal manometry (HRAM), and Vaizey incontinence score in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed HRAM in 45 adults (26 females and 19 males), and all subjects completed the Vaizey incontinence score questionnaire after enrollment in this prospective study. The diagnosis of fecal incontinence is defined by Rome IV criteria and a Vaizey incontinence score &gt;\u20095. The contraction power during short and endurance squeezes was quantified by calculating the SSCI and ESCI in the HRAM study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in the incontinence group (<jats:italic>n<\/jats:italic>\u2009=\u200912) had significantly lower maximum pressure at short squeeze, SSCI, and ESCI (<jats:italic>p<\/jats:italic>\u2009=\u20090.001 and 0.004, respectively) than patients in the continence group (<jats:italic>n<\/jats:italic>\u2009=\u200933). The ROC curve analysis identified the SSCI &lt;\u200965\u2009000\u2009mmHg\u00b7s\u00b7cm achieved the highest area under the curve for predicting fecal incontinence than the ESCI and the maximum pressure at short squeeze maneuver (77.30%, 74.00%, and 71.15%, respectively). The logistic regression further confirms the SSCI &lt;\u200965\u2009000\u2009mmHg\u00b7s\u00b7cm is associated with fecal incontinence after adjusting age and sex (odds ratio\u2009=\u20097.30, <jats:italic>p<\/jats:italic>\u2009=\u20090.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel SSCI indicates the adequacy of contraction power during short squeeze by HRAM in adult patients and correlates with fecal incontinence. The correlation between SSCI and Vaizey incontinence score is higher than the traditional measurement of HRAM in adults with fecal incontinence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.17001","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:10:49Z","timestamp":1748351449000},"page":"1728-1735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short and Endurance Squeeze Contractile Integral in High\u2010Resolution Anorectal Manometry Is Correlated With Vaizey Incontinence Score\u2014A Pilot Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6343-1658","authenticated-orcid":false,"given":"Jia\u2010Feng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Departments of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzung\u2010Hsin","family":"Chou","sequence":"additional","affiliation":[{"name":"Departments of Emergency National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-7538","authenticated-orcid":false,"given":"Ping\u2010Huei","family":"Tseng","sequence":"additional","affiliation":[{"name":"Departments of Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u2010Jung","family":"Tsai","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Chuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao\u2010Kai","family":"Yang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Electronics Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Hsiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Electronics Engineering National Taiwan University  Taipei Taiwan"},{"name":"Department of Electrical Engineering National Taiwan University  Taipei 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