{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:25:06Z","timestamp":1789500306816,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few large\u2010scale studies exist on within\u2010country variations in the incidence, diagnosis, and mortality of small intestine malignancies. This study examined the epidemiological trends and outcomes of these cancers in South Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed National Health Insurance Service claims data from 2005 to 2022 to identify newly diagnosed small intestine malignancies (ICD\u201010 code C17) and evaluated treatment modalities and diagnostic test usage. Kaplan\u2013Meier curves and Cox proportional hazards models assessed survival outcomes and prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 20\u2009395 newly diagnosed patients with small intestine malignancies. Incidence rose over the study period, with a temporary decline during COVID\u201019 in 2019\u20132020, followed by a sharp increase in 2021. The highest incidence was among individuals aged 60\u201369, particularly in regions with larger elderly populations. Diagnostic procedures increased from 3.27 per person in 2005 to 6.23 in 2022. Patients with advanced adenocarcinoma treated with chemotherapy had a 5\u2010year survival rate of 23.8% (95% CI 21.7\u201325.8), while those with advanced gastrointestinal stromal tumor treated with imatinib had a rate of 75.5% (95% CI 73.4\u201377.6). Older age and lack of surgery were linked to poorer outcomes in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of malignant neoplasms of the small intestine has risen over time, likely due to enhanced diagnostic efforts, with regional variations highlighting the influence of demographic factors such as age. Improving survival outcomes requires a better understanding of these demographic factors and a stronger focus on early detection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.17014","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T23:04:36Z","timestamp":1748819076000},"page":"1910-1918","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["National Insights Into Epidemiological Trends and Outcomes of Malignant Neoplasms of the Small Intestine: A Big Data Analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"Jung\u00a0Rock","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Inje University Ilsanpaik Hospital  Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-0085","authenticated-orcid":false,"given":"Joo\u00a0Hye","family":"Song","sequence":"additional","affiliation":[{"name":"Konkuk University Medical Center Konkuk University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyoun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Soonchunhyang University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u2010My","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Soonchunhyang University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-4638","authenticated-orcid":false,"given":"Hyun\u00a0Gun","family":"Kim","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, Institute for Digestive Research Soonchunhyang University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Oh","family":"Kim","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, Institute for Digestive Research Soonchunhyang University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6970-9737","authenticated-orcid":false,"given":"Seong\u00a0Ran","family":"Jeon","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, Institute for Digestive Research Soonchunhyang University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u00a0Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Asan Institute for Life Sciences, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Small Intestine Research Group of the Korean Association for the Study of Intestinal Diseases (KASID)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197408000-00008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2173-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000562"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04344-z"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-005-3635-6"},{"issue":"2","key":"e_1_2_6_7_1","first-page":"81","article-title":"Increasing Incidence of Adenocarcinomas and Carcinoid Tumors of the Small Intestine in Adults","volume":"5","author":"Severson R. 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