{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:41:01Z","timestamp":1783698061287,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and aim<\/jats:title><jats:p>Laryngopharyngeal cancers are often overlooked during endoscopy because of their anatomical complexity and the gag reflex. However, the characteristics of these cancers remain poorly understood. We studied the differences in clinical characteristics and endoscopic procedures between missed and detected cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Newly diagnosed laryngopharyngeal squamous cell carcinomas identified during esophagogastroduodenoscopy at our hospital between January 2016 and December 2020 were analyzed. A total of 179 lesions were categorized into two groups: missed (<jats:italic>n<\/jats:italic>\u2009=\u200974) and detected (<jats:italic>n<\/jats:italic>\u2009=\u2009105). Missed cancer was defined as a lesion identified within 18\u2009months of preceding esophagogastroduodenoscopy at our hospital, while detected cancer was defined as a lesion not included in the missed group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The miss rate of laryngopharyngeal cancers on esophagogastroduodenoscopy was 41.3%. Multivariate analysis showed that the non\u2010use rate of pethidine hydrochloride (odds ratio 4.1, 95% confidence interval 2.0\u20138.6, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), ratio of white\u2010light imaging \u2265 narrow\u2010band imaging through observation of laryngopharynx (odds ratio 31.8, 95% confidence interval 3.9\u2013258.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and number of \u201ccomprehensiveness of laryngopharyngeal observation\u201d negatives (odds ratio 2.6, 95% confidence interval 1.3\u20135.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) were significantly larger in the missed group. Univariate analysis showed that the number of tumors located on the epiglottis (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) was significantly larger in the missed group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights the importance of precisely observing the laryngopharynx, facilitated by the use of pethidine hydrochloride and narrow\u2010band imaging. In addition, epiglottic lesions are frequently missed. Comprehensive observation of the laryngopharynx using narrow\u2010band imaging and premedication may reduce the frequency of missed cancers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.17023","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T10:39:59Z","timestamp":1748515199000},"page":"2037-2045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differences in Clinical Characteristics Between Missed and Detected Laryngopharyngeal Cancers"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7551-4938","authenticated-orcid":false,"given":"Yusuke","family":"Kumazawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Ikenoyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Gastroenterology and Hepatology Mie University Hospital  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Department of Pathology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Division of Pathology Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koyo","family":"Kido","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Gastroenterology and Hepatology Mie University Hospital  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3220-8645","authenticated-orcid":false,"given":"Ken","family":"Namikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-4405","authenticated-orcid":false,"given":"Yoshitaka","family":"Tokai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Yoshimizu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo 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