{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:00Z","timestamp":1787015460367,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study is to compare the clinical outcomes of surgical resection (SR) and radiofrequency ablation (RFA) in patients with early\u2010stage hepatocellular carcinoma (HCC) and Child\u2013Pugh Class B liver function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 7210 treatment\u2010na\u00efve HCC patients in our group between 2000 and 2021, this retrospective study included 41 and 456 patients who underwent SR and RFA, respectively. All included patients had Child\u2013Pugh Class B liver function, an Eastern Cooperative Oncology Group (ECOG) performance status of \u2264\u20092, and early\u2010stage HCC (\u2264\u20093 nodules, \u2264\u20093\u2009cm in diameter). To adjust for baseline imbalances between the two groups, we applied inverse probability of treatment weighting (IPTW) analysis. Recurrence\u2010free survival (RFS) and overall survival (OS) were assessed using Kaplan\u2013Meier survival analysis and Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Before IPTW analysis, significant differences were observed between the SR and RFA groups in Child\u2013Pugh scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), total bilirubin levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), prothrombin time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), and the presence of ascites (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), all of which were more favorable in the SR group. The SR group also had fewer tumors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and larger tumor diameters (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) compared to the RFA group. In the entire cohort, there were no significant differences in RFS between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.6). After IPTW analysis, the differences remained statistically nonsignificant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.4). Regarding OS, the difference was not observed between the two groups in the entire cohort (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.5) and in the IPTW cohort (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.9).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RFA appears to be as effective as SR in patients with early\u2010stage HCC with the liver function of Child\u2013Pugh Class B.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.17025","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T03:39:28Z","timestamp":1748317168000},"page":"2068-2077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Surgical Resection and Radiofrequency Ablation for Early\u2010Stage HCC Patients With Child\u2013Pugh Class B"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3656-285X","authenticated-orcid":false,"given":"Takeshi","family":"Hatanaka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Gunma Saiseikai Maebashi Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-7093","authenticated-orcid":false,"given":"Satoru","family":"Kakizaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Research NHO Takasaki General Medical Center  Takasaki Japan"},{"name":"Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-0480","authenticated-orcid":false,"given":"Atsushi","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-6761","authenticated-orcid":false,"given":"Toshifumi","family":"Tada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3996-7502","authenticated-orcid":false,"given":"Kazuya","family":"Kariyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Okayama City Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0475-2819","authenticated-orcid":false,"given":"Ei","family":"Itobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asahi General Hospital  Asahi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4152-9364","authenticated-orcid":false,"given":"Kunihiko","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Center of Gastroenterology Teine Keijinkai Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-9694","authenticated-orcid":false,"given":"Toru","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Niigata Hospital  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Koshiyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-0102","authenticated-orcid":false,"given":"Atsushi","family":"Naganuma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology NHO Takasaki General Medical Center  Takasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8639-5212","authenticated-orcid":false,"given":"Yuki","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Gunma Saiseikai Maebashi Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9811-2665","authenticated-orcid":false,"given":"Kazunari","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Center of Gastroenterology Teine Keijinkai Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3964-5876","authenticated-orcid":false,"given":"Fujimasa","family":"Tada","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-824X","authenticated-orcid":false,"given":"Hideko","family":"Ohama","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2018-0008","authenticated-orcid":false,"given":"Kazuhiro","family":"Nouso","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Okayama City Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5065-9669","authenticated-orcid":false,"given":"Shinichiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Japanese Red Cross Society Himeji Hospital  Himeji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5871-3802","authenticated-orcid":false,"given":"Takashi","family":"Kumada","sequence":"additional","affiliation":[{"name":"Gifu Kyoritsu University  Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Real\u2010life Practice Experts for HCC (RELPEC) Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000466"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.08.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521665"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13411"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514174"},{"key":"e_1_2_8_8_1","volume-title":"Clinical Practice Manual for Hepatocellular Carcinoma","author":"The Japan Society of Hepatology","year":"2020"},{"key":"e_1_2_8_9_1","volume-title":"Evidence Based Clinical Practice Guideline for Hepatocellular Carcinoma (2017 Updated Version)","author":"The Japan Society of Hepatology","year":"2017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2019.12.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000201480.65519.b8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12441"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.05.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181efc656"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2018.94.2.74"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10677"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-009-0239-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010007\u20100392\u20108"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.17025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T13:49:19Z","timestamp":1754056159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.17025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jgh.17025"],"URL":"https:\/\/doi.org\/10.1111\/jgh.17025","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,27]]},"assertion":[{"value":"2025-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}