{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:42:11Z","timestamp":1790286131033,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The Asia\u2010Pacific region faces serious liver health challenges, primarily because of the comparatively high prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, as well as the increasing disease burden of metabolic\u2010associated steatotic liver disease (MASLD), alcohol\u2010associated liver disease, and hepatocellular carcinoma (HCC). Despite MASLD being the cause with the highest growth rate worldwide, chronic HBV or HCV infection remains a prominent cause of HCC in the Asia\u2010Pacific region. Despite widespread vaccination and the use of oral nucleos(t)ide analogs, the risk of HCC persists in patients with chronic HBV infection, and a customized surveillance program for HCC should be implemented. Because there are currently no effective vaccinations for chronic HCV infection, universal screening and link\u2010to\u2010care with appropriate costs for direct\u2010acting antivirals are required. Furthermore, patients with chronic HCV infection who have achieved a sustained virological response (SVR) are still at risk of developing HCC, even if HCV eradication with antivirals significantly lowers that risk. Identifying candidates for whom HCC surveillance is consistently necessary, using surrogate indicators and risk classification, should be investigated. Targeted multidisciplinary research is required to address these issues. Finally, combining data science and biotechnology with artificial intelligence applications in healthcare can improve therapeutic and diagnostic results, particularly in regions with limited resources.<\/jats:p>","DOI":"10.1111\/jgh.17028","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:52:49Z","timestamp":1748339569000},"page":"1855-1860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Future Perspectives of Liver Research in the Asia\u2010Pacific Region: Focus on Hepatitis B and C"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5363-2496","authenticated-orcid":false,"given":"Beom\u00a0Kyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Yonsei Liver Center, Severance Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0055-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.01.045"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.05.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2023.0277"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2023.0291"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30579-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-016-9745-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.12.116"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.016"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.1.65"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0342"},{"key":"e_1_2_10_13_1","article-title":"2022 KLCA\u2010NCC Korea Practice Guidelines for the Management of Hepatocellular Carcinoma","volume":"23","author":"Korean Liver Cancer Association","year":"2023","journal-title":"Journal of Liver Cancer"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0163"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0506"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.09.025"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000584"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0434"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.02.036"},{"key":"e_1_2_10_20_1","unstructured":"https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/hepatitis\u2010c."},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i34.7824"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i4.1684"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12697"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(09)60231-X"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149362"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4346(96)82012-3"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(98)00119-3"},{"key":"e_1_2_10_28_1","first-page":"888","article-title":"A Sero\u2010Epidemiological Study on Hepatitis C in China","volume":"32","author":"Chen Y. 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