{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:56:07Z","timestamp":1755222967180,"version":"3.43.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100020788","name":"Science and Technology Major Project of Inner Mongolia Autonomous Region of China","doi-asserted-by":"publisher","award":["2023YFHH0090"],"award-info":[{"award-number":["2023YFHH0090"]}],"id":[{"id":"10.13039\/501100020788","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460347"],"award-info":[{"award-number":["82460347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Accurate staging is crucial for effective treatment of hepatic fibrosis (HF). This study evaluates whether spectral CT\u2010derived liver iron concentration (LIC) quantification correlates with HF stages and validates its efficacy in diagnostic staging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred seventy\u2010five New Zealand white rabbits were included in the prospective study (35 normal controls; 140 HF models). Rabbits underwent spectral CT scans before modeling and at 4, 6, 8, 10, and 12\u2009weeks. HF was staged by METAVIR system. Using iodine and water as reference materials paired with iron, the original LIC and the normalized LIC (NIC\u2009=\u2009LIC\/aortic\u2010iron) were measured. The material decomposition (MD) technique of spectral CT was used to quantify LIC and evaluate the correlation between HF stage and LIC. ANOVA, chi\u2010square, and ROC were employed using SPSS, Python, and MedCalc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred fifty rabbits (30\u2010per\u2010stage, F0\u2013F4) were selected. LIC<jats:sub>iron(iodine)<\/jats:sub> and NIC<jats:sub>iron(iodine)<\/jats:sub> in the noncontrast (NC) phase, and LIC<jats:sub>iron(water)<\/jats:sub> and NIC<jats:sub>iron(water)<\/jats:sub> in arterial phases (AP), increased with HF progression (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) consistent with pathological results. Multiple LIC parameters exhibited significant differences in 126 comparisons (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). ROC showed excellent diagnostic performance of NIC<jats:sub>iron(water)<\/jats:sub>\u2010AP across HF stages (AUC: 0.884\u20131.000), especially in distinguishing F1 from F0, F2, F3, and F4 (AUC: 0.979, 0.979, 0.918, 0.934). NIC<jats:sub>iron(iodine)<\/jats:sub>\u2010NC exhibited moderate efficacy in F0 versus F1 (AUC\u2009=\u20090.767) but high in other stages (AUC: 0.826\u20130.994). A multiparameter model achieved a macro\u2010AUC of 0.9917.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Spectral CT\u2013based liver iron concentration quantification demonstrates a strong correlation with HF stages, providing precise HF staging and excellent diagnostic performance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.17031","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T10:59:51Z","timestamp":1749725991000},"page":"2104-2118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron Quantification Using Spectral CT\u2013Based Material Decomposition Technique for Noninvasive Hepatic Fibrosis Staging: An Experimental Study"],"prefix":"10.1111","volume":"40","author":[{"given":"Lu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Baotou Medical College  Baotou 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