{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:54:04Z","timestamp":1773014044216,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>High\u2010volume polyethylene glycol (PEG) solutions are associated with low patient compliance, whereas low\u2010volume alternatives pose higher risks of adverse events. We compared a new 0.8\u2010L PEG\u2013ascorbic acid solution containing simethicone to a 2\u2010L PEG\u2013ascorbic acid solution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, investigator\u2010blinded study, 137 outpatients from five centers were randomized into three groups: Group A (0.8\u2010L PEG\u2013ascorbic acid with a split\u2010dose regimen), Group B (0.8\u2010L PEG\u2013ascorbic acid on the same day as the colonoscopy), and Group C (2\u2010L PEG\u2013ascorbic acid with a split\u2010dose regimen). The primary outcome was the cleansing efficacy, assessed using the Harefield Cleansing Scale (HCS). Secondary outcomes included bubble score, polyp and adenoma detection rates, patient satisfaction, tolerability, and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All groups achieved 100% successful preparation (HCS grades A and B). Group B had a higher HCS grade in the ascending colon than Group C (3.2 vs. 3.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Groups A and B showed better bubble scores than Group C (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Polyp and adenoma detection rates were similar across the groups. Group B demonstrated the highest satisfaction score (139.1\u2009\u00b1\u200976.7), followed by Group A (129.8\u2009\u00b1\u200964.9) and Group C (125.6\u2009\u00b1\u200960.0), with no significant differences. The tolerability and safety parameters were similar between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel 0.8\u2010L PEG\u2013ascorbic acid solution was effective, safe, and highly tolerable, showing noninferiority to the 2\u2010L PEG\u2013ascorbic acid solution. The same\u2010day regimen showed a tendency toward better cleansing efficacy in the ascending colon and higher patient satisfaction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.70006","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T09:38:34Z","timestamp":1753349914000},"page":"2248-2257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative Efficacy and Safety of 0.8\u2010L Versus 2\u2010L Polyethylene Glycol\u2010Ascorbic Acid Solutions in Colonoscopy Preparation: A Prospective, Multicenter, Randomized, Controlled Trial"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6519-4168","authenticated-orcid":false,"given":"Bomee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology Korea University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-1945","authenticated-orcid":false,"given":"Bora","family":"Keum","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology Korea University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-3717","authenticated-orcid":false,"given":"Sung\u00a0Noh","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-4638","authenticated-orcid":false,"given":"Hyun\u00a0Gun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Soonchunhyang University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u00a0Pil","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Young","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u00a0Seob","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwangwoo","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dankook University Hospital, Dankook University College of Medicine  Cheonan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9793-6379","authenticated-orcid":false,"given":"Jeong\u2010Sik","family":"Byeon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center, University of Ulsan College of Medicine  Seoul South 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