{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:11:21Z","timestamp":1791821481446,"version":"4.3.4"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["22\u20102038"],"award-info":[{"award-number":["22\u20102038"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      The effect of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      (\n                      <jats:italic>H.\u2009pylori<\/jats:italic>\n                      ) infection and eradication on the risk of gastroesophageal reflux disease (GERD) is still unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a systematic review with a comprehensive literature search in the bibliographic databases Embase, Medline, and Cochrane Library through May 2024. Random\u2010effects meta\u2010analyses estimated the pooled odds ratios (OR) for the associations of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection and eradication with GERD risk in prospective studies. A two\u2010sample Mendelian randomization analysis based on data from the FinnGen study assessed associations between genetically predicted levels of seven\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      antibodies, that is, immunoglobulin G (IgG) and six virulence factors (cytotoxin\u2010associated gene A [CagA], Outer Membrane Protein [OMP], vacuolating cytotoxin A [VacA], urease A [UreA], catalase and GroEL), and GERD risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 25 eligible studies were included. Meta\u2010analysis combining data from three cohort studies and one nested case\u2013control study indicated an inverse association between\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection and GERD (pooled OR\u2009=\u20090.58; 95% confidence interval [CI], 0.23\u20131.44). Meta\u2010analysis of 18 cohort studies and three randomized controlled trials (RCTs) showed an increased risk of GERD after\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication (pooled OR\u2009=\u20092.01; 95% CI, 1.44\u20132.81), and this association was stronger when specifically analyzing reflux esophagitis (pooled OR\u2009=\u20092.27; 95% CI, 1.57\u20133.29). No associations were found in Mendelian randomization analysis for any of the studied\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      antibodies. [Correction added on 7 August 2025, after first online publication: The Abstract section has been updated to correct the number of studies for eligible and cohort under the Results.]\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The study suggests that\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection is associated with a decreased risk of GERD and that\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u2009pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication increases the risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70009","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T10:35:15Z","timestamp":1752575715000},"page":"2391-2401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    Infection and Eradication in Relation to Gastroesophageal Reflux Disease"],"prefix":"10.1111","volume":"40","author":[{"given":"Hejie","family":"Wang","sequence":"first","affiliation":[{"name":"School of Public Health Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Qu","sequence":"additional","affiliation":[{"name":"School of Public Health Fujian Medical University  Fuzhou 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