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However, it is uncertain whether NLR reflects the immunologic portrait or the molecular subtype of pancreatic cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Total 64 pancreatic cancer patients who underwent surgical resection were enrolled and their preoperative serum NLR was calculated. Immunohistochemistry for CD8, CD15, CK5, and GATA6 was performed on tumor tissues to investigate the immunologic microenvironment or molecular subtype of the tumor. \u0394Np63 transfection in pancreatic cancer cell lines and subsequent cytokine array were done to investigate the mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the clinicopathologic analyses, high\u2010NLR (\u2265\u20093.29) was associated with adenosquamous histology (<jats:italic>p<\/jats:italic>\u2009=\u20090.009) and the significantly worse overall (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) or disease\u2010free survivals (<jats:italic>p<\/jats:italic>\u2009=\u20090.044). In line with the value of serum NLR, tumors in the high\u2010NLR group contained more neutrophils (<jats:italic>p<\/jats:italic>\u2009=\u20090.0198) but fewer T lymphocytes (<jats:italic>p<\/jats:italic>\u2009=\u20090.0463) than in the low\u2010NLR group. Most of the tumors in the high\u2010NLR group were determined to be the basal\u2010like subtype (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). Transfection of \u0394Np63, a known key transcription factor driving the basal\u2010like subtype, led to a substantial increase of CCL5, which is a potent chemokine to recruit neutrophils.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High preoperative NLR is a simple but reliable biomarker predicting a worse prognosis in pancreatic cancer patients, mechanistically because this reflects a suppressive immune microenvironment and also is strongly linked to the aggressive basal\u2010like subtype. Our study provides a rationale to use the NLR for tailored therapy as well as for predicting prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.70016","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T07:50:09Z","timestamp":1753170609000},"page":"2623-2631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High Neutrophil\u2010to\u2010Lymphocyte Ratio Predicts a Suppressive Immune Microenvironment and Basal\u2010Like Subtype in Pancreatic Cancer"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5039-8182","authenticated-orcid":false,"given":"Min\u00a0Jae","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine  Suwon Republic of 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