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Steatotic liver disease (SLD)\u2013related single nucleotide polymorphisms (SNPs) were tested, and a polygenetic risk score (PRS) for hepatocellular carcinoma was created.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The annual incidence of HCC was 1.7\/100 person\u2010years after a follow\u2010up of &gt;\u20093346.9 person\u2010years. Factors with the strongest association with HCC were liver cirrhosis (hazard ratio [HR]\/95% confidence interval [CI]: 4.51\/2.12\u20139.62; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), followed by male sex (4.20\/1.64\u201310.79; <jats:italic>p<\/jats:italic>\u2009=\u20090.003), a sSLD\u2010related PRS &gt;\u20090.062 (2.24\/1.09\u20134.58; <jats:italic>p<\/jats:italic>\u2009=\u20090.03), body mass index (BMI) (1.15\/1.07\u20131.24; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and age (1.06\/1.03\u20131.10; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Among patients without cirrhosis, the HCC\u2010associated factors were male sex (HR\/CI: 1.17\/1.10\u20131.24; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and BMI (1.16\/1.03\u20131.30; <jats:italic>p<\/jats:italic>\u2009=\u20090.01). In contrast, a high PRS (HR\/CI: 2.57\/1.19\u20135.57; <jats:italic>p<\/jats:italic>\u2009=\u20090.02) was the only HCC\u2010associated factor in patients with cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SLD\u2010related gPRS predicted HCC development in CHB patients treated with NAs. The genetic effects were particularly enhanced in patients with cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.70021","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:21:39Z","timestamp":1753345299000},"page":"2290-2299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Steatotic Liver Disease\u2010Related Polygenetic Risk Score Prediction of Hepatocellular Carcinoma in Nucleotide\/Nucleoside Analog\u2010Treated Chronic Hepatitis B"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-130X","authenticated-orcid":false,"given":"Tyng\u2010Yuan","family":"Jang","sequence":"first","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Pingtung Hospital Ministry of Health and Welfare  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