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Six randomized controlled trials have compared chemotherapy with chemoradiotherapy in patients with locally advanced pancreatic cancer (LAPC), but these trials only involved conventional external beam radiotherapy. Over the last decade, stereotactic body radiation therapy (SBRT) has risen to prominence over conventional external beam radiotherapy. Moreover, endoscopic ultrasound (EUS)\u2010guided brachytherapy has been used in a trial setting, though it is not routinely used in LAPC. In this review, we report a meta\u2010analysis of randomized controlled trials that have compared chemotherapy with chemoradiotherapy and review two\u2010arm trials assessing survival outcomes with chemotherapy and SBRT over chemotherapy only. 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