{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:26:54Z","timestamp":1782973614248,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The use of glucagon\u2010like peptide\u20101(GLP\u20101) receptor agonists has revolutionized the treatment of Type 2 diabetes mellitus and morbid obesity. They are known to slow gastric emptying and potentially increase the risk of pulmonary aspiration perioperatively. We aim to conduct a retrospective study to evaluate the risk of aspiration pneumonia in patients on GLP\u20101 receptor agonists undergoing colonoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A large research network (TriNetX LLC) comprising over 100 million patients was leveraged to obtain data from 2016 to 2024. Patients who underwent colonoscopy during the study period were divided into GLP\u20101 users and non\u2010users. The primary outcomes were aspiration pneumonia and hospitalization following colonoscopy. The secondary outcomes were respiratory failure and the need for mechanical ventilation within 7\u2009days of colonoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Before propensity score matching, the study included 126\u2009663 patients on GLP\u20101 agonists and 1\u2009380\u2009652 not on GLP\u20101 agonists. Propensity score matching resulted in balanced cohorts of 126\u2009663 patients per group. After propensity score matching, the risk ratio for aspiration pneumonia in the GLP\u20101 agonist group was 0.70 (95% confidence interval, 0.50\u20130.98), suggesting a trend towards reduced risk and does not suggest increased risk of aspiration pneumonia. Similarly, no significant differences were observed in mechanical ventilation, respiratory failures, or hospitalization rates between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This large retrospective study shows no increased risk of aspiration pneumonia with GLP\u20101 agonist use, in patients undergoing screening colonoscopy. These findings suggest that minimally sedated gastroscopy prior to colonoscopy, routine GLP\u20101 agonist withholding, and overly restrictive fasting are not required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70071","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T03:10:31Z","timestamp":1757992231000},"page":"2732-2737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Unmasking Aspiration Risks: A Propensity\u2010Matched Odyssey of GLP\u20101 Receptor Agonists and Colonoscopy"],"prefix":"10.1111","volume":"40","author":[{"given":"Puneet","family":"Chhabra","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Royal Hobart Hospital  Hobart Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Royal Hobart Hospital  Hobart Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rituraj","family":"Singh","sequence":"additional","affiliation":[{"name":"College of Medicine University of Illinois  Peoria Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13162"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212283"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17020199"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","unstructured":"M. A.Kalas T. Q.Dang G.Galura et\u00a0al. \u201cFrequency of GLP\u20101 Receptor Agonists Use in Diabetic Patients Diagnosed With Delayed Gastric Emptying and Their Demographic Profile \u201d71(2022):11\u201316.","DOI":"10.1136\/jim-2022-002480"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-333036"},{"key":"e_1_2_8_7_1","unstructured":"S. L.Hocking D. A.Scott andM. L.Remedios \u201cClinical Practice Recommendations Regarding Patients Taking GLP\u20101 Receptor Agonists and Dual GLP\u20101\/GIP Receptor Co\u2010Agonists Prior to Anaesthesia or Sedation for Surgical and Endoscopic Procedures \u201d (2025)."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2024.10.057"},{"key":"e_1_2_8_9_1","unstructured":"\u201cPublication Guidelines \u2013 TriNetX \u201d TriNetX (2025)."},{"key":"e_1_2_8_10_1","unstructured":"B.Malin Malin \u201cSummary of the Assessment of Trinetx Data Privacy Principles Through an Empirical Analysis \u201d (2020)."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16099"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004776"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2023.111091"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2023.07.016"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.14005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-023-02440-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-023-02521-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2023.05.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anr3.12278"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.11.024"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16601"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.0081"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16541"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:22:14Z","timestamp":1762201334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.70071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,15]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/jgh.70071"],"URL":"https:\/\/doi.org\/10.1111\/jgh.70071","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,15]]},"assertion":[{"value":"2025-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}