{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:34:15Z","timestamp":1762202055509,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100018925","name":"Health Commission of Henan Province","doi-asserted-by":"publisher","award":["SBGJ202103021"],"award-info":[{"award-number":["SBGJ202103021"]}],"id":[{"id":"10.13039\/100018925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010ERCP biliary tract infection (PEBTI) poses significant risks, but the impact of prior gastrointestinal infection remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, prospective cohort study of choledocholithiasis patients undergoing elective ERCP evaluated PEBTI incidence over 1\u2009month. Directed acyclic graphs (DAGs) were used to conceptualize the roles of measured variables in PEBTI susceptibility, and inverse probability of treatment weighting (IPTW) was applied to balance confounders. The association between prior gastrointestinal infection and PEBTI was evaluated using Cox regression. Sensitivity analyses were further performed with trimmed\/stabilized IPTW and E\u2010value calculation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1507 enrolled patients, 604 (40.0%) reported prior gastrointestinal infection. The cumulative incidence of PEBTI was 5.4% in patients with prior gastrointestinal infection compared to 4.2% in those without (unadjusted HR\u2009=\u20091.32; 95% CI: 0.83\u20132.10;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.246). After IPTW adjustment, the hazard of PEBTI increased significantly (HR\u2009=\u20092.71, 95% CI: 1.24\u20135.92,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), of which 20.3% was mediated by preoperative gastrointestinal colonization. Sensitivity analyses confirmed the robustness of this association (trimmed\/stabilized IPTW HR\u2009=\u20092.89 and 2.67,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prior gastrointestinal infection independently elevates PEBTI risk. Findings highlight the need for tailored prophylactic strategies alongside current guidelines and mechanistic explorations to mitigate post\u2010ERCP infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70072","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:36:39Z","timestamp":1757586999000},"page":"2738-2749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prior Gastrointestinal Infection and Risk of Post\u2010ERCP Biliary Tract Infection in Patients With Choledocholithiasis: A Prospective Cohort Study"],"prefix":"10.1111","volume":"40","author":[{"given":"Yin","family":"Chen","sequence":"first","affiliation":[{"name":"Gastrointestinal Endoscopy Center Henan Provincial People's Hospital, People's Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Gastroenterology Department Henan Provincial People's Hospital, People's Hospital of Zhengzhou 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