{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:56:50Z","timestamp":1781636210073,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Celiac disease (CeD) is a multisystem disease and may coexist in patients with cirrhosis. We aimed to assess (1) CeD prevalence in all\u2010cause cirrhosis, (2) the impact of a gluten\u2010free diet (GFD) on liver\u2010related outcomes in definite CeD, and (3) characteristics and follow\u2010up of patients with positive celiac serology and cirrhosis without enteropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1959 consecutive patients with cirrhosis were screened for CeD using IgA anti\u2010tissue transglutaminase antibody. All those having elevated anti\u2010tTG Ab underwent anti\u2010endomysial Ab testing and duodenal biopsies. Patients with definite CeD matched with those without CeD (1:4; CeD: no CeD matched for age, sex, baseline CTP, and MELD) were initiated on GFD plus standard of care (SOC) and SOC and followed up for 1\u2009year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Definite CeD was identified in 35 of 1959 (1.8%; 95% CI: 1.2%\u20132.4%) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935; mean age: 37.3\u2009\u00b1\u200912.3; Child\u2013Pugh Stage A\/B\/C: 17.1%\/57.1%\/25.7%; median MELD 19 [IQR: 17\u201322]), whereas the prevalence of positive celiac serology without enteropathy was 140 of 1959 (7.2%; 95% CI: 6.0%\u20138.3%). New\u2010onset liver decompensations (34.3% vs. 44.3%) and mortality (17.1% vs. 13.6%) were similar in patients with CeD on GFD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935) and the matched (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009140) cohort without CeD over 1\u2009year, but liver stiffness measurement decreased significantly in patients with CeD (28.5\u2009\u00b1\u200914.3 vs. 41.2\u2009\u00b1\u200918.31;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Patients with definite CeD showed normalization of celiac serology on GFD. One\u2010year follow\u2010up IgA tTG normalized in 88 of 122 (72.1%) patients with positive celiac serology without enteropathy without GFD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with cirrhosis of the liver, irrespective of underlying etiology, should be screened for CeD. Early diagnosis of CeD and GFD may improve prognosis and clinical outcomes in patients with cirrhosis of the liver.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70082","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T06:39:31Z","timestamp":1760683171000},"page":"2857-2866","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Celiac Disease and Its Impact on Liver\u2010Related Outcomes in Patients With All\u2010Cause Cirrhosis: The CELIHEP Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-9112","authenticated-orcid":false,"given":"Ankit","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Human Nutrition Unit All India Institute of Medical Sciences  New Delhi 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