{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:55:54Z","timestamp":1792007754578,"version":"4.4.0"},"reference-count":77,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Incretin\u2010based therapies include glucagon\u2010like peptide\u20101 single, dual, and triple receptor agonists (GLP\u20101 RAs) and dipeptidyl peptidase\u20104 (DPP\u20104) inhibitors. This meta\u2010analysis aimed to assess the efficacy of incretin\u2010based therapies for metabolic dysfunction\u2013associated steatotic liver disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, the Cochrane Library, and EMBASE for relevant studies published before December 6, 2024. The outcomes of interest included liver histology, liver fat content (LFC), liver function, serum lipid profiles, anthropometric profiles, glycosylated hemoglobin (HbA1c), and gastrointestinal side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This meta\u2010analysis included 32 randomized controlled trials with 2783 participants. The pooled data showed that GLP\u20101RAs were associated with resolution of metabolic dysfunction\u2013associated steatohepatitis without worsening of fibrosis (relative risk [RR] 3.33, 95% confidence interval [CI] 2.38\u20134.66,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009\n                      <jats:italic>=<\/jats:italic>\n                      \u200912.9%) and could decrease the levels of LFC (weighted mean difference [WMD] \u22124.34%, 95% CI \u22125.88 to \u22122.81,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009\n                      <jats:italic>=<\/jats:italic>\n                      \u200995.3%). GLP\u20101 RAs could also significantly reduce liver function, serum triglyceride, body weight, body mass index (BMI), waist circumference (WC), and HbA1c while increasing the risk of gastrointestinal side effects. However, DPP\u20104 inhibitors had no significant effect on the above indicators except for HbA1c (WMD \u22120.62%, 95% CI \u22120.91 to \u22120.33,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009\n                      <jats:italic>=<\/jats:italic>\n                      \u20090%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta\u2010analysis revealed that GLP\u20101RAs improved liver histology, LFC, liver function, and a variety of metabolic parameters in MASLD patients, whereas DPP\u20104 inhibitors had no apparent effect except for lowering HbA1c. Incretin\u2010based therapies, especially GLP\u20101 RAs, may be candidate treatments for patients with MASLD but may increase the incidence of gastrointestinal side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70084","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T09:58:48Z","timestamp":1759226328000},"page":"2659-2673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of Incretin\u2010Based Therapies in Patients With Metabolic Dysfunction\u2013Associated Steatotic Liver Disease: An Updated Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"40","author":[{"given":"Lili","family":"Liu","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Metabolic Syndrome Research Center The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Metabolic Syndrome Research Center The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6725-0369","authenticated-orcid":false,"given":"Yiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.08.026"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2024.02.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00193-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.962834"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-020-00536-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12525"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25115640"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02045-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.07.033"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2014.08.013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0399-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102782"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-018-9674-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.09.010"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.156038"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23569"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1544"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02462.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13026"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30320"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4100-7"},{"key":"e_1_2_8_24_1","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page M. 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