{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:29:56Z","timestamp":1789414196269,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670529"],"award-info":[{"award-number":["81670529"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870414"],"award-info":[{"award-number":["81870414"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CD100 is a positive regulator for immune responses. In HBV infection, CD100 can regulate immune cell activation for antiviral responses, raising the possibility that it might become a potential target for the treatment of HBV\u2010related liver cirrhosis. However, the CD100 impact on hepatocytes and its influence in HBV\u2010related liver cirrhosis have yet to be determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The sCD100 in the serum and the CD100 on platelets were analyzed in HBV\u2010infected patients. The effects of CD100 stimulation on primary human hepatocytes (PHHs) and the gene expressions in human liver tissues during HBV\u2010related liver cirrhosis were examined by mRNA\u2010microarray analysis. GO and PPI enrichments were used to evaluate shared genes of CD100\u2010regulated genes in PHHs and changed genes in liver tissues. The influence of CD100 on the activation of hepatic stellate cells (HSCs) and extracellular matrix deposition was assessed in a PHHs and HSCs co\u2010culture system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The serum sCD100 and CD100 on platelets, which possess the potential to directly interact with hepatocytes, were downregulated in HBV\u2010infected patients. The CD100 stimulation induced immune responses, elevated the expression of TGF\u2010\u03b2 antagonists and HNF4A\u2010related genes, and inhibited ECM deposition in the PHHs and HSCs co\u2010culture system. CD100 modulated the gene expression in PHHs through plexin B1 and B2 signal transduction, which activated the ERK and STAT3 signaling pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CD100 stimulation on PHHs induced anti\u2010cirrhosis gene expression and suppressed HSCs activation through ERK and STAT3 signaling, which may potentially serve as a target for the treatment of HBV\u2010related liver cirrhosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70123","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T01:19:14Z","timestamp":1761095954000},"page":"3018-3029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Effects of CD100 Stimulation on Primary Human Hepatocytes (PHHs) and Its Implications in HBV\u2010Related Liver Cirrhosis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3834-6483","authenticated-orcid":false,"given":"Chao","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"He","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuantao","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqi","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of General Surgery Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Tangdu Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801644"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01435"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060516676136"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-015-0379-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113338"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.05.013"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2020.0311"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.52.33376"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3257-7"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16843"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23062938"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)02087-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.12.012"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13189"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297919090049"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.65"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-021-00406-y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb843"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.026"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.035600"},{"issue":"5","key":"e_1_2_11_22_1","first-page":"769","article-title":"Guidelines for Prevention and Treatment of Chronic Hepatitis B","volume":"9","author":"Wang G.","year":"2021","journal-title":"Journal of Clinical and Translational Hepatology"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2485"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.08.011"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201707112"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01610-15"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-324848"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i38.5849"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03674.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i18.3228"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.10.008"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-022-00907-5"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-022-00713-y"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2021.12.002"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.09.005"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9395-0"},{"issue":"5","key":"e_1_2_11_38_1","first-page":"712","article-title":"Role of Inhibition of Osteogenesis Function by Sema4D\/Plexin\u2010B1 Signaling Pathway in Skeletal Fluorosis In\u00a0Vitro","volume":"35","author":"Liu X. L.","year":"2015","journal-title":"Journal of Huazhong University of Science and Technology. Medical Sciences"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00459-7"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705467200"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.139"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.16.6889-6898.2005"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26296-7"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T09:25:02Z","timestamp":1764581102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.70123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/jgh.70123"],"URL":"https:\/\/doi.org\/10.1111\/jgh.70123","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,21]]},"assertion":[{"value":"2025-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}