{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:53:24Z","timestamp":1773748404295,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172637"],"award-info":[{"award-number":["82172637"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303240"],"award-info":[{"award-number":["82303240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82220108013"],"award-info":[{"award-number":["82220108013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20379"],"award-info":[{"award-number":["U20A20379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The efficacy of neoadjuvant chemotherapy (NAC) combined with surgery and postoperative adjuvant chemotherapy in improving the prognosis of locally advanced gastric cancer (LAGC) has been confirmed. Nevertheless, there is still no effective tool to predict the response to NAC in gastric cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included a total of 184 patients (118 in the training cohort and 66 in the testing cohort) treated with oxaliplatin\u2009+\u2009fluorouracil\u2010based NAC from January 2010 to July 2022. Immunohistochemistry staining of biomarkers was carried out on the endoscopy biopsy specimens before receiving treatment. Logistic regression was performed to explore the predictive biomarkers of response to NAC, and internal verification was carried out by using the bootstrap method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Ferroptosis increased significantly in NAC\u2010sensitive LAGC. Among the molecular markers related to ferroptosis, Fe\n                      <jats:sup>2+<\/jats:sup>\n                      , ACSL4, DHODH, GCH1, and FSP1 showed significant differences between the sensitive and nonsensitive groups. Logistic regression analysis revealed Fe\n                      <jats:sup>2+<\/jats:sup>\n                      , ACSL4, DHODH, and GCH1 as predictors of the efficacy of NAC. A nomogram prediction model was established based on identified biomarkers. The area under the ROC curve (AUC) of the nomogram model was 0.89, which indicated that the prediction results of the model were highly consistent with the actual situation (Hosmer\u2013Lemeshow test\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.684). The AUC of the nomogram model in the external validation set (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200966) was 0.82, indicating that the model has certain predictive ability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study revealed the critical value of biomarkers related to ferroptosis serving as novel predictive biomarkers for patients with LAGC receiving NAC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70124","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:35:48Z","timestamp":1761536148000},"page":"2913-2924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development and Validation of a New Prediction Criteria for Neoadjuvant Chemotherapy Response in Locally Advanced Gastric Cancer Based on Ferroptosis\u2010Related Biomarkers"],"prefix":"10.1111","volume":"40","author":[{"given":"Minxuan","family":"Shen","sequence":"first","affiliation":[{"name":"Digestive Medicine Center, The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"},{"name":"Guangdong Provincial Key Laboratory of Digestive Cancer Research  Shenzhen Guangdong China"},{"name":"Research Center for Diagnosis and Treatment of Gastric Cancer Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-4319","authenticated-orcid":false,"given":"Qinbo","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The First Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"General Surgery Laboratory, The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 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Medical College  Shantou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqun","family":"Wang","sequence":"additional","affiliation":[{"name":"Digestive Medicine Center, The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"},{"name":"Guangdong Provincial Key Laboratory of Digestive Cancer Research  Shenzhen Guangdong China"},{"name":"Research Center for Diagnosis and Treatment of Gastric Cancer Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongman","family":"Xie","sequence":"additional","affiliation":[{"name":"Digestive Medicine Center, The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"},{"name":"Guangdong Provincial Key Laboratory of Digestive Cancer Research  Shenzhen Guangdong China"},{"name":"Research Center for Diagnosis and Treatment of Gastric Cancer Sun Yat\u2010sen University  Guangzhou Guangdong 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