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Varespladib, an sPLA\n                      <jats:sub>2<\/jats:sub>\n                      inhibitor, has shown potential to treat a variety of inflammatory diseases. Its role in colonic inflammation caused by a HFD remains to be studied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>C57\/BL6 mice were fed a chow diet (NCD), HFD, or HFD with varespladib for 4\u2009weeks. Various parameters were measured to assess the effects of varespladib on HFD\u2010induced metabolic changes. The TGF\u2010\u03b2\/Smad and the arachidonic acid pathway were analyzed using RT\u2010qPCR and western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Varespladib supplementation in HFD\u2010fed mice led to reduced body weight and abdominal adiposity, improved intestinal health and blood lipid profiles, mitigated intestinal inflammation and fibrosis, downregulated genes associated with immunity and permeability, and inhibited key inflammatory pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Short\u2010term HFD induced intestinal inflammation. These disorders are mainly triggered by sPLA\n                      <jats:sub>2<\/jats:sub>\n                      upregulation, resulting in activation of the arachidonic acid and TGF\u2010\u03b2\/smad pathways. Varespladib has significant therapeutic potential for alleviating HFD\u2010induced colonic inflammation in mice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70130","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T23:53:42Z","timestamp":1761004422000},"page":"2933-2943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Varespladib Alleviates Colonic Inflammation Induced by High\u2010Fat Diet via Downregulating the TGF\u2010\u03b2\/Smad Pathway and AA Pathway by Inhibiting sPLA\n                    <sub>2<\/sub>"],"prefix":"10.1111","volume":"40","author":[{"given":"Meng","family":"Shirui","sequence":"first","affiliation":[{"name":"Queen Mary School, Jiangxi Medical College Nanchang University  Nanchang 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