{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:01:04Z","timestamp":1792166464126,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>Liraglutide, a glucagon\u2010like\u2010peptide\u20101 (GLP\u20101) receptor agonist, improves hepatic steatosis and metabolic parameters. We evaluated the impact of liraglutide on liver stiffness (LS) and steatosis by vibration\u2010controlled transient elastography (VCTE) and metabolic parameters in patients with metabolic dysfunction\u2010associated steatotic liver disease (MASLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 197 patients with MASLD who received liraglutide between 2020 and 2023. VCTE assessed changes in LS values and controlled attenuation parameter (CAP). Metabolic parameters, including body mass index (BMI), glycemic markers, and lipid profiles, were evaluated at baseline, 2\u2009months, and 6\u2009months after liraglutide treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median follow\u2010up duration was 5.9\u2009months. Of 197 patients, 172 had follow\u2010up data at 2\u2009months and 142 at 6\u2009months. At baseline, mean LS and CAP were 7.5\u2009kPa and 327\u2009dB\/m. CAP significantly decreased at 2\u2009months (mean \u0394\u2009\u2212\u200926.0\u2009dB\/m,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), but not at 6\u2009months (mean \u0394\u2009\u2212\u200920.6\u2009dB\/m,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.384). LS showed no significant change at either time point (mean 7.0\u2009kPa at 2\u2009months and 7.2\u2009kPa at 6\u2009months; all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). BMI (from 30.9 to 28.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), HbA1c (from 6.3% to 6.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.352), and homeostatic model assessment of insulin resistance (HOMA\u2010IR) improved significantly over 6\u2009months, and the proportion of patients meeting MASLD criteria declined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Liraglutide improved hepatic steatosis and metabolic parameters, not LS, in patients with MASLD, though its effect on LS was limited. These findings support the favorable influence of liraglutide on MASLD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70134","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:10:56Z","timestamp":1762416656000},"page":"2976-2986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Impact of Liraglutide on Patients With Metabolic Dysfunction\u2013Associated Steatotic Liver Disease"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0545-9427","authenticated-orcid":false,"given":"Jae\u00a0Eun","family":"So","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine  Seoul South 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u00a0Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine  Seoul South Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-3439","authenticated-orcid":false,"given":"Do\u00a0Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul South Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine  Seoul South Korea"},{"name":"Yonsei Liver Center Severance Hospital  Seoul South 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