{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:01:20Z","timestamp":1785344480936,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170555"],"award-info":[{"award-number":["82170555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270569"],"award-info":[{"award-number":["82270569"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000507"],"award-info":[{"award-number":["82000507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Patients with reflux\u2010related esophageal stricture after POEM were clinically similar to patients with recurrent achalasia, such as dysphagia and regurgitation. This study aimed to compare the clinical differences between reflux\u2010related stricture and recurrent achalasia, as well as to evaluate the efficacy and safety of endoscopic treatment for reflux\u2010related stricture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From June 2015 to January 2023, we reviewed 1946 patients with achalasia who underwent POEM. Among these, data from 42 patients with reflux\u2010related strictures and 151 patients with recurrence after POEM were collected. After propensity score matching (PSM), baseline characteristics and procedure\u2010related parameters were retrospectively evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With similar baseline characteristics between the two groups after PSM, the reflux\u2010related stricture group showed higher rates of regurgitation, heartburn, mucosal edema, mucosal ulcer, and grade C\/D esophagitis compared with the recurrence group. The mean LES resting pressure on high\u2010resolution manometry (HRM) was lower in the reflux\u2010related stricture than in the recurrence group (2.8\u2009\u00b1\u20095.3 vs. 21.1\u2009\u00b1\u200916.7\u2009mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). Nine endoscopic radial incisions (ERI), eight endoscopic balloon dilations (EBD), and 25 proton pump inhibitors were administered in patients with reflux\u2010related esophageal stricture after POEM. At follow\u2010up of 24\u2009months, the rate of re\u2010stricture was similar between the ERI and EBD groups (33.3% vs. 50.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.637). Multivariate analysis revealed submucosal fibrosis was associated with reflux\u2010related stricture after POEM (OR 2.367, 95% CI 1.274\u20135.618,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite symptomatic similarities, reflux\u2010related stricture and recurrent achalasia after POEM could be distinguished by symptoms, HRM, and endoscopic presentations. Furthermore, ERI and EBD are safe and effective treatments for reflux\u2010related esophageal stricture after POEM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70143","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:32:06Z","timestamp":1766449926000},"page":"248-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment and Management of Reflux\u2010Related Esophageal Stricture After Peroral Endoscopic Myotomy in Achalasia"],"prefix":"10.1111","volume":"41","author":[{"given":"Shao\u2010Bin","family":"Luo","sequence":"first","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu\u2010Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"},{"name":"Endoscopy Center Shanghai Geriatric Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yan","family":"Cai","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan\u2010Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5434-0540","authenticated-orcid":false,"given":"Ping\u2010Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Collaborative Innovation Center of Endoscopy  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Endoscopy Center, Zhongshan Hospital Fudan University (Xiamen Branch)  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-021-02376-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-015-3031-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.06.027"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1312-0496"},{"key":"e_1_2_9_6_1","first-page":"155","article-title":"Efficacy and Safety of Peroral Endoscopic Myotomy in the Management of Recurrent Achalasia After Failed Heller Myotomy: A Systematic Review and meta\u2010Analysis","volume":"34","author":"Kamal F.","year":"2021","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-023-10196-6"},{"key":"e_1_2_9_8_1","first-page":"134","article-title":"Repeat Peroral Endoscopic Myotomy: A Salvage Option for Persistent\/Recurrent Symptoms","volume":"48","author":"Li Q. 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