{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:41:08Z","timestamp":1790401268763,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["115\u2010S0157"],"award-info":[{"award-number":["115\u2010S0157"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The diagnostic accuracy and optimal cutoff values of serum Mac\u20102 binding protein glycosylation isomer (M2BPGi) for predicting hepatic fibrosis severity in hepatitis C virus (HCV)\u2013infected patients with and without metabolic dysfunction\u2013associated steatotic liver disease (MASLD) remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 2064 patients with available M2BPGi data and valid vibration\u2010controlled transient elastography (VCTE) results. The areas under the receiver operating characteristic curves (AUROCs) with 95% confidence intervals (CIs) of M2BPGi were compared between MASLD and non\u2010MASLD groups for fibrosis stages of \u2265F2, \u2265F3, and F4. M2BPGi cutoff values were determined for the maximal Youden index, positive likelihood ratio (LR+) nearest to \u226510, and negative LR (LR\u2010) nearest to \u22640.1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the same fibrosis stage, serum M2BPGi levels were significantly higher in MASLD patients than in non\u2010MASLD patients (F0\u2013F1: 1.12 versus 1.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011; F2: 2.02 versus 1.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013; F3: 3.13 versus 3.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023; F4: 5.32 versus 4.91,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). The AUROCs of M2BPGi were comparable between MASLD and non\u2010MASLD groups for \u2265F2 (0.899 [95% CI: 0.878\u20130.919] versus 0.889 [95% CI: 0.871\u20130.908]), \u2265F3 (0.914 [95% CI: 0.892\u20130.936] versus 0.934 [95% CI: 0.915\u20130.952]), and F4 (0.917 [95% CI: 0.894\u20130.941] versus 0.953 [95% CI: 0.937\u20130.968]). Optimal cutoff levels for all criteria were higher in patients with MASLD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum M2BPGi is a reliable marker for assessing hepatic fibrosis severity in HCV patients. However, optimal cutoff values should be adjusted according to MASLD status to improve diagnostic accuracy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70160","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T14:03:12Z","timestamp":1763128992000},"page":"322-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictive Value of Serum Mac\u20102 Binding Protein Glycosylation Isomer for Hepatic Fibrosis in Hepatitis C Virus\u2013Infected Patients With Metabolic Dysfunction\u2013Associated Steatotic Liver Disease"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7543-7547","authenticated-orcid":false,"given":"Yun\u2010Chu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ping","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Biomedical Park Hospital  Hsin\u2010Chu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Yuh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital, Yun\u2010Lin Branch  Douliou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Ditmanson Medical Foundation Chiayi Christian Hospital  Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Yu","family":"Kao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Metabolism and Obesity Sciences Taipei Medical University  Taipei Taiwan"},{"name":"TMU Research Center for Digestive Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Taipei Cancer Center Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Taipei City Hospital, Ren\u2010Ai Branch  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Shun","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Kuan Tien General Hospital  Taichung 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Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4503-3255","authenticated-orcid":false,"given":"Fu\u2010Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Fu Jen Catholic University Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Chung Shan Medical University Hospital  Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang\u2010Chin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Bei\u2010Hu Branch  Taipei 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