{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:15:13Z","timestamp":1792084513889,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n Increasing antibiotic resistance rates and cost constraints necessitate optimized\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n therapies. This trial compared the efficacy, safety, and cost\u2010effectiveness of vonoprazan\u2013amoxicillin dual therapy versus bismuth quadruple therapy for\n \n H.\u2009pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication using China's centralized procurement antibiotics.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this multicenter, randomized, controlled trial, 534 treatment\u2010na\u00efve\n \n H.\u2009pylori<\/jats:italic>\n <\/jats:styled-content>\n \u2010infected patients were assessed, with 450 patients ultimately assigned to the VNCDPA\u2010dual (vonoprazan 20\u2009mg BID\u2009+\u2009amoxicillin 1\u2009g TID), B\u2010quadruple (esomeprazole 20\u2009mg BID\u2009+\u2009non\u2010procurement amoxicillin 1\u2009g BID\u2009+\u2009clarithromycin 500\u2009mg BID\u2009+\u2009bismuth 600\u2009mg BID), or BNCDPA\u2010quadruple group (same as B\u2010quadruple but with amoxicillin obtained via centralized procurement). Eradication rates were assessed using the urea breath test [per\u2010protocol (PP) and intention\u2010to\u2010treat (ITT) analyses]. Adverse events (AEs) and costs were systematically evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eradication rates were comparable among groups [92.1% (B\u2010quadruple) vs. 90.7% (BNCDPA\u2010quadruple) vs. 91.7% (VNCDPA\u2010dual) in PP analysis (\n p<\/jats:italic>\n \u2009=\u20090.889); 85.3% vs. 84.7% vs. and 88.0% in ITT analysis (\n p<\/jats:italic>\n \u2009=\u20090.947)]. VNCDPA\u2010dual demonstrated superior safety, with significantly fewer AEs (6.8% vs. 17.9%\u201319%;\n p<\/jats:italic>\n \u2009=\u20090.003), particularly dysgeusia (1.4% vs. 15.2%\u201315.6%;\n p<\/jats:italic>\n \u2009<\u20090.001). Centralized procurement amoxicillin reduced costs by 44% (\u00a5239 per course vs. \u00a5315 per course) without compromising efficacy. Compliance was highest in the VNCDPA\u2010dual group (99% vs. 95.9.7%\u201395.2% in the quadruple groups,\n p<\/jats:italic>\n \u2009<\u20090.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study confirms that 10\u2010day vonoprazan\u2013amoxicillin dual therapy (using National Centralized Drug Procurement antibiotics) demonstrates noninferior efficacy to bismuth quadruple therapy while offering superior safety, better compliance, and the advantage of shorter treatment duration. These findings support its adoption as a first\u2010line regimen for large\u2010scale\n \n H.\u2009pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication programs.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.70179","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T03:00:53Z","timestamp":1764730853000},"page":"649-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Randomized Comparison of Vonoprazan\u2013Amoxicillin Dual Therapy Versus Bismuth Quadruple Therapies for\n \n Helicobacter pylori<\/i>\n <\/scp>\n Eradication: A Multicenter Trial Evaluating National Centralized Drug Procurement Antibiotics"],"prefix":"10.1111","volume":"41","author":[{"given":"Youyu","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Wujin Hospital Affiliated to Jiangsu University Changzhou 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