{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:19:36Z","timestamp":1789391976784,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Branch\u2010duct intraductal papillary mucinous neoplasms (BD\u2010IPMNs) are characterized by a relatively slow progression to malignant transformation. We aimed to evaluate the natural history of BD\u2010IPMNs over 10\u2009years, focusing on clinical changes associated with malignancy and identifying predisposing factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 308 patients with BD\u2010IPMN monitored for up to 10\u2009years to evaluate the development of pancreatic carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort comprised 308 patients with a median follow\u2010up of 67.2\u2009months (range: 6\u2013234). Of these, 197 had long\u2010term follow\u2010up data (\u2265\u20095\u2009years). At 5\u2009years, the cumulative incidence of pancreatic carcinoma was 2.1%, including 0.7% for IPMN\u2010derived invasive carcinoma and 1.4% for de novo pancreatic ductal adenocarcinoma (PDAC). At 10\u2009years, the cumulative incidence increased to 5.5%, with 2.7% for IPMN\u2010derived carcinoma and 2.9% for de novo PDAC. In multivariate analysis, cyst wall thickening (odds ratio [OR]: 23.471; 95% confidence interval [CI]: 5.617\u201398.072;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and rapid cyst growth (OR: 9.761; 95% CI: 1.145\u201382.431;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037) were independently associated with carcinoma. In separate analyses, cyst wall thickening was the only factor independently associated with both IPMN\u2010derived invasive carcinoma (OR: 41.765; 95% CI: 3.992\u2013436.943;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and de novo PDAC (OR: 10.000; 95% CI: 1.570\u201363.708;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The cumulative incidence of both IPMN\u2010derived invasive carcinoma and de novo PDAC reached 5.5% at 10\u2009years. Cyst wall thickening was identified as an independent risk factor. Larger studies are warranted to refine risk stratification and optimize surveillance strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70185","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:35:45Z","timestamp":1764549345000},"page":"352-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010Term Surveillance for Pancreatic Carcinoma Among Patients With Branch\u2010Duct Intraductal Papillary Mucinous Neoplasms"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3225-4351","authenticated-orcid":false,"given":"Gaeun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine Chung\u2010Ang University College of Medicine  Seoul Republic of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-0329","authenticated-orcid":false,"given":"Yoo\u00a0Shin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1830-9666","authenticated-orcid":false,"given":"Seung\u00a0Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-0478","authenticated-orcid":false,"given":"Hyun\u00a0Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology Chung\u2010Ang University College of Medicine  Seoul Republic of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1008-9814","authenticated-orcid":false,"given":"Tae\u00a0Yoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Konkuk University Hospital Konkuk University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3767-504X","authenticated-orcid":false,"given":"Tae\u00a0Young","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0068-5030","authenticated-orcid":false,"given":"Hyoung\u2010Chul","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Chung\u2010Ang University College of Medicine  Seoul Republic of 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