{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:52:37Z","timestamp":1788871957660,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Gastric varices (GV) are a major complication of portal hypertension, with a high risk of severe bleeding. Conventional endoscopic glue injection or endoscopic ultrasound (EUS) directed therapies have been used for treatment. However, each has its limitations. EUS\u2010guided combination of coil and glue injection has emerged as a potential strategy to improve outcomes. This meta\u2010analysis compares the efficacy and safety of EUS\u2010coil and glue to other endoscopic modalities in GV management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Five databases were systematically searched until October 2024. Data were pooled using risk ratios (RRs) with 95% confidence intervals (CIs) via a random\u2010effect model. Heterogeneity was assessed using the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistic, and subgroup and sensitivity analyses were performed. The risk of bias in studies and the certainty of the evidence were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine studies with 579 patients met the inclusion criteria. Compared with other modalities, EUS\u2010coil and glue had a lower risk of reintervention (RR\u2009=\u20090.32, 95% CIs\u2009=\u20090.21\u20130.50) and a higher rate of GV obliteration (RR\u2009=\u20091.18, 95% CIs\u2009=\u20091.03\u20131.37). There was no significant difference in mortality risk (RR\u2009=\u20090.87, 95% CIs\u2009=\u20090.54\u20131.40). The overall risk of adverse events (RR\u2009=\u20090.55, 95% CIs\u2009=\u20090.34\u20130.90) was lower, particularly rebleeding (RR\u2009=\u20090.36, 95% CIs\u2009=\u20090.22\u20130.59). The certainty of evidence ranged from very low to moderate due to bias and study heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EUS\u2010coil and glue injection offers superior efficacy and a favorable safety profile compared with other endoscopic treatments for GV. However, the quality of the evidence warrants further well\u2010designed studies to assess long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70190","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:54:24Z","timestamp":1765241664000},"page":"413-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Endoscopic Ultrasound\u2010Guided Coiling Plus Glue Injection Compared With Other Endoscopic Modalities in Managing Gastric Varices: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"41","author":[{"given":"Zinat","family":"Mohammadpour","sequence":"first","affiliation":[{"name":"College of Medicine and Dentistry James Cook University  Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Castrejon\u00a0Moreno","sequence":"additional","affiliation":[{"name":"College of Medicine and Dentistry James Cook University  Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobak","family":"Moazzami","sequence":"additional","affiliation":[{"name":"Northside Hospital Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjivan","family":"Mudaliar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"},{"name":"University of Queensland School of Medicine  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Trasolini","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Vancouver General Hospital  Vancouver British Columbia 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