{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:32:41Z","timestamp":1793781161467,"version":"4.6.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007723","name":"Takeda Pharmaceuticals U.S.A.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>We examined post hoc the effect of budesonide oral suspension (BOS\/Eohilia) 2.0\u2009mg twice daily (b.i.d.) on dysphagia symptom outcomes in patients with eosinophilic esophagitis (EoE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients aged 11\u201355\u2009years who received BOS 2.0\u2009mg b.i.d. or placebo during phase 2 or phase 3, 12\u2010week, double\u2010blind, placebo\u2010controlled clinical trials (MPI 101\u201006 and SHP621\u2010301) were included. The Kaplan\u2013Meier method captured time to first dysphagia symptom response (\u2265\u200930% reduction in the Dysphagia Symptom Questionnaire [DSQ] score from baseline). Efficacy outcomes using the DSQ at weeks 4, 8, and 12 of therapy were: the proportion of patients with complete dysphagia symptom resolution; change from baseline in the number of dysphagia\u2010free days; and the proportion of patients with dysphagia symptoms, but without adaptive behaviors or pain. Each outcome was measured based on daily DSQ records in the 2\u2009weeks before each study visit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 411 patients from MPI 101\u201006 (BOS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200951; placebo,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942) and SHP621\u2010301 (BOS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009213; placebo,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009105) were included. Median time to first dysphagia symptom response was significantly shorter for BOS\u2010 than placebo\u2010treated patients (MPI 101\u201006,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0239; SHP621\u2010301,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0156), with separation between groups at week 2, the earliest time point measured. At all time points, higher proportions of BOS\u2010 than placebo\u2010treated patients had complete dysphagia symptom resolution or had dysphagia symptoms but no adaptive behaviors or pain. BOS\u2010 versus placebo\u2010treated patients also had greater improvements from baseline in the number of dysphagia\u2010free days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BOS is efficacious in managing dysphagia in EoE across several symptom metrics.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>ClinicalTrials.gov:<\/jats:bold>\n                      NCT01642212; NCT02605837.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70205","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:15:49Z","timestamp":1771506949000},"page":"927-936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Budesonide Oral Suspension on Time to First Dysphagia Symptom Response and Dysphagia Symptom Resolution Outcomes in Patients With Eosinophilic Esophagitis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-1101","authenticated-orcid":false,"given":"Evan\u00a0S.","family":"Dellon","sequence":"first","affiliation":[{"name":"Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0A.","family":"Katzka","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent\u00a0A.","family":"Mukkada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary\u00a0W.","family":"Falk","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muna\u00a0J.","family":"Tahir","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas, Inc.  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u00a0Cristian","family":"Gugiu","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals USA, Inc.  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessamyn","family":"Blau","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas, Inc.  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Terreri","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals USA, Inc.  Lexington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616689525"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003194"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17430"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.09.004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.04.020"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.11.021"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.04.022"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.06.020"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2205982"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.07.039"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-017-0006-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12413"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.03.060"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2024.100302"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15000"},{"key":"e_1_2_11_19_1","unstructured":"Takeda Pharmaceuticals America Inc. \u201cPrescribing Information EOHILIA (Budesonide Oral Suspension) \u201d US Food and Drug Administration (2024) https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/213976s000lbl.pdf."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.12.018"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002094"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-08205-8"},{"key":"e_1_2_11_23_1","first-page":"S\u2010230","article-title":"Fluticasone Propionate Oral Disintegrating Tablet, APT\u20101011, Leads to a Greater Complete Symptomatic Response Rate Compared to Placebo in Subjects With Eosinophilic Esophagitis (EoE)","volume":"166","author":"Dellon E. 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