{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:58:32Z","timestamp":1792180712722,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Intraductal papillary neoplasms of the bile duct (IPN\u2010Bs), recognized as potential precursors of invasive cholangiocarcinoma, present diagnostic challenges due to their variable imaging characteristics, mucin production, and frequent tumor multiplicity. Conventional imaging modalities may be limited in accurately characterizing these lesions. We assessed the clinical utility of peroral cholangioscopy (POC) in the diagnosis and management of IPN\u2010Bs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>IPN\u2010Bs were diagnosed in consecutive patients who underwent POC, based on a comprehensive assessment of clinical presentation, laboratory findings, imaging studies, and POC results. The primary outcome was the detection rate of IPN\u2010Bs. The secondary outcomes were the technical success of POC and POC\u2010guided forceps biopsy (POC\u2010FB), diagnostic accuracy of POC findings, procedure\u2010related adverse events (AEs), detection rate of IPN\u2010Bs missed on prior imaging, and management modification rate after POC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>POC was completed in 599 of 631 patients (94.9%). Mild procedure\u2010related AEs occurred in nine patients (1.4%) and were managed conservatively. IPN\u2010Bs were identified in 84 patients (13.3%), including 25 (29.8%) that had not been detected on prior imaging. Among the 81 of 84 patients in whom POC\u2010FB was successful, histopathologic diagnoses included indefinite for dysplasia (17.3%), low\u2010grade dysplasia (53.1%), high\u2010grade dysplasia (13.6%), and invasive carcinoma (16.0%). Among 59 patients with suspected IPN\u2010Bs on conventional imaging, POC findings led to management modifications in 17 cases (20.2%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>POC is a useful diagnostic modality for the detection of IPN\u2010Bs and facilitates accurate decision\u2010making for subsequent management planning.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      KCT0010599\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70206","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T02:09:49Z","timestamp":1767060589000},"page":"803-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Utility of Peroral Cholangioscopy in the Diagnosis and Management of Intraductal Papillary Neoplasms of the Bile Duct (With Videos)"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2199-1942","authenticated-orcid":false,"given":"Il\u00a0Sang","family":"Shin","sequence":"first","affiliation":[{"name":"Digestive Disease Center, Department of Internal Medicine SoonChunHyang University College of Medicine  Bucheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-9944","authenticated-orcid":false,"given":"Jong\u00a0Ho","family":"Moon","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, Department of Internal Medicine SoonChunHyang University College of Medicine  Bucheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u00a0Nah","family":"Lee","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, Department of Internal Medicine SoonChunHyang University College of Medicine  Bucheon 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