{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:52:34Z","timestamp":1792641154752,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Biliary tract cancers (BTCs)\u2014including cholangiocarcinoma and gallbladder cancer\u2014are increasing in incidence worldwide and carry a poor prognosis, constituting a growing global health burden. Early\u2010stage disease can be potentially cured with surgical resection; however, the majority present with advanced disease, and palliative systemic therapy is the mainstay of treatment. In the first\u2010line setting, gemcitabine plus cisplatin (GemCis) chemotherapy served as the long\u2010standing standard of care; subsequently, TOPAZ\u20101 and KEYNOTE\u2010966 established GemCis plus durvalumab or pembrolizumab as the current standard. For patients who progressed after frontline therapy and lack actionable alterations, fluoropyrimidine plus oxaliplatin and fluoropyrimidine plus liposomal irinotecan are recommended second\u2010line options, supported by ABC\u201006 and NIFTY, respectively. Several targeted agents have demonstrated clinically meaningful efficacy in phase 2\u20133 trials and are recommended as subsequent\u2010line therapy for biomarker\u2010selected disease, including\n                    <jats:italic>FGFR2<\/jats:italic>\n                    gene rearrangements,\n                    <jats:italic>IDH1<\/jats:italic>\n                    mutations, and\n                    <jats:italic>HER2<\/jats:italic>\n                    amplification. Although recent advances have improved clinical outcomes in patients with advanced BTC, median overall survival remains around 1\u2009year, underscoring the need for further therapeutic innovation. This review provides a comprehensive overview of the current standards of care and highlights emerging therapeutic strategies for advanced BTC.\n                  <\/jats:p>","DOI":"10.1111\/jgh.70208","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T02:39:54Z","timestamp":1766457594000},"page":"516-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Systemic Therapy for Advanced Biliary Tract Cancers in 2026: Current Standard of Care and Emerging Therapeutic Strategies"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4502-8021","authenticated-orcid":false,"given":"Hyunseok","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Oncology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of 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