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While endoscopic screening enables early detection and improves prognosis, it requires substantial healthcare resources and specialized manpower. Growing evidence supports population\u2010based\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    screening and eradication as an effective and cost\u2010efficient primary prevention strategy, enabling elimination of the etiological factor while directing endoscopic resources toward individuals at the highest risk. Randomized controlled trials and cohort studies, predominantly from Asian countries, have demonstrated significant reductions in gastric cancer incidence following successful\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    treatment. To maximize the impact of this strategy, implementation should follow the principles of an organized screening program, with clearly structured pathways for invitation, testing, treatment, and outcome monitoring. Test selection must be tailored to local prevalence and healthcare capacity, and eradication regimens should be guided by regional antibiotic resistance patterns to achieve high cure rates while upholding antibiotic stewardship. Integrating\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    screening into existing preventive services can further enhance cost\u2010effectiveness and population coverage. Ongoing challenges include managing antibiotic resistance, stratifying the residual risk of gastric cancer after eradication to inform endoscopic surveillance, and ensuring consistent quality and equity of screen\u2010and\u2010treat programs across different healthcare systems.\n                  <\/jats:p>","DOI":"10.1111\/jgh.70209","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T02:55:16Z","timestamp":1766458516000},"page":"532-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Population\u2010Based\n                    <scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    Screening for Gastric Cancer Prevention: Opportunities and Challenges in Asia"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-9756","authenticated-orcid":false,"given":"Tsung\u2010Hsien","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Medicine National Taiwan University  Taipei City Taiwan"},{"name":"Department of Integrated Diagnostics and Therapeutics National Taiwan University Hospital  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-080X","authenticated-orcid":false,"given":"Shu\u2010Lin","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Medical Research National Taiwan University Hospital  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8682-5825","authenticated-orcid":false,"given":"Teresa\u00a0Cheng\u2010Chieh","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Medical Research National Taiwan University Hospital  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-1216","authenticated-orcid":false,"given":"Yi\u2010Chia","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine National Taiwan University  Taipei City Taiwan"},{"name":"Department of Medical Research National Taiwan University Hospital  Taipei City Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay J.","year":"2024"},{"key":"e_1_2_12_3_1","volume-title":"Population\u2010Based Helicobacter pylori Screen\u2010and\u2010Treat Strategies for Gastric Cancer Prevention: Guidance on Implementation (IARC Working Group Reports No. 12)","author":"Park J. 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