{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:55:55Z","timestamp":1781812555146,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974383"],"award-info":[{"award-number":["81974383"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273321"],"award-info":[{"award-number":["82273321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>This study aimed to develop and validate a survival prediction model for patients with gastroesophageal variceal bleeding treated with combined sclerotherapy and cyanoacrylate injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patient data were retrospectively collected and randomly divided into training and validation cohorts (7:3). Key prognostic variables in the training cohort were identified using random survival forest (RSF), least absolute shrinkage and selection operator (LASSO) regression, and extreme gradient boosting (XGBoost). A nomogram was developed with the Cox proportional hazards model. Kaplan\u2013Meier (KM) curves assessed stratified survival, SHapley Additive exPlanations (SHAP) analysis interpreted variable contributions, and bootstrap resampling was used for internal validation. Model performance was evaluated by receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The concordance index for 1\u2010 and 3\u2010year survival was 0.736 and 0.735 in the training cohort and 0.847 and 0.865 in the validation cohort. Time\u2010dependent ROC analysis showed AUCs of 0.736 (95% CI: 0.648\u20130.824) and 0.735 (95% CI: 0.657\u20130.813) in the training cohort and 0.869 (95% CI: 0.794\u20130.944) and 0.879 (95% CI: 0.812\u20130.945) in the validation cohort. Calibration curves demonstrated good agreement, and DCA confirmed substantial net clinical benefit across threshold probabilities ranging from 0.2 to 0.6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prognostic nomogram integrating age, MELD score, and the risk of rebleeding after combined endoscopic therapy demonstrated good clinical applicability and may provide a valuable reference for individualized treatment and follow\u2010up management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70212","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:16:36Z","timestamp":1768378596000},"page":"705-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nomogram Predicting Survival in Gastroesophageal Variceal Bleeding Treated With Sclerotherapy and Cyanoacrylate"],"prefix":"10.1111","volume":"41","author":[{"given":"Yingzhi","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linggui","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Northeast Yunnan Regional Central Hospital  Zhaotong Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0228-7626","authenticated-orcid":false,"given":"Wei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei 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