{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:55:04Z","timestamp":1781812504331,"version":"3.54.5"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>IgG4\u2010associated autoimmune hepatitis (IgG4\u2010AIH) is an emerging entity characterized by overlapping features of classical autoimmune hepatitis (AIH) and IgG4\u2010related disease (IgG4\u2010RD). However, significant heterogeneity in diagnostic criteria has obscured its true prevalence and clinical significance. This systematic review aimed to characterize the clinical, serological, and histopathological features of IgG4\u2010AIH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA guidelines, a systematic search was conducted across PubMed, Embase, and Web of Science. Study selection, data extraction, and quality assessment using Joanna Briggs Institute (JBI) tools were performed independently by two reviewers. A narrative synthesis was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 43 studies (11 cohort studies, 32 case reports and series) describing 185 patients were included. The cohort was predominantly of Asian origin and showed a female predominance. The most common autoantibody was antinuclear antibody (73%\u201378%), while serum IgG4 levels were highly variable but exceeded the 135\u2010mg\/dL threshold in all cases. Histopathologically, interface hepatitis and plasma cell infiltration were frequent features, and advanced fibrosis (Stages 3\u20134) was noted in approximately half the patients. Concurrent IgG4\u2010RD was significantly more prevalent in case\u2010based studies versus cohort studies (58% vs. 8.2%, respectively). Glucocorticoid therapy demonstrated high efficacy, with over 70% of patients achieving biochemical remission within three months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review characterizes IgG4\u2010AIH as a distinct clinical entity bridging classical AIH and IgG4\u2010RD. Its unique clinical and pathological profile underscores the need for consensus diagnostic criteria and prospective studies to determine optimal management strategies and long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70213","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:55:17Z","timestamp":1767678917000},"page":"443-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["IgG4\u2010Associated Autoimmune Hepatitis: a Systematic Review"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4052-2634","authenticated-orcid":false,"given":"Chun\u2010Hsun","family":"Liao","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei 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