{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:55:21Z","timestamp":1781812521076,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) is a major global health concern, with molecular and histopathological subtypes influencing disease progression. Mutations in the v\u2010Raf murine sarcoma viral oncogene homolog B (BRAF) gene, particularly the V600E variant, define a subset associated with aggressive features. The impact of BRAF mutations on early\u2010stage CRC prognosis and their interaction with mismatch repair (MMR) status remains less characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of prospectively collected data from two tertiary institutions on Stage II\u2013III CRC patients. BRAF\/MMR subgroups were defined (BRAFmut\/pMMR, BRAFmut\/dMMR, BRAFwt\/pMMR, and BRAFwt\/dMMR). Associations with patient\/tumor characteristics, adjuvant treatment, and long\u2010term outcomes were assessed. Univariate and multivariate analyses were used to evaluate disease recurrence and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 157 eligible patients, univariate analyses indicated poorer outcomes for those with pMMR CRC. Multivariate analysis examining disease recurrence and death highlights that pMMR patients perform worse, but significantly, this analysis revealed that BRAFmut is a significant predictor of mortality in the nonmetastatic setting, irrespective of MMR status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Nonmetastatic BRAFmut CRC carries a dismal prognosis, irrespective of MMR status. Routine testing for BRAF\n                      <jats:sup>V600E<\/jats:sup>\n                      mutation alongside MMR assessment is advocated to inform personalized management, potentially impacting surveillance, adjuvant therapy decisions, and eligibility for targeted therapies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70215","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:17:17Z","timestamp":1769167037000},"page":"667-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of BRAF Gene Mutation in Nonmetastatic Colorectal Cancer on Disease Progression and Survival Outcomes"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-4588","authenticated-orcid":false,"given":"Caroline","family":"Lum","sequence":"first","affiliation":[{"name":"Department of Anatomy and Developmental Biology Monash University  Clayton Australia"},{"name":"Stem Cells and Development Program, Monash Biomedicine Discovery Institute Monash University  Clayton Australia"},{"name":"Department of Oncology Monash Health  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1992-4635","authenticated-orcid":false,"given":"Harrison","family":"Boka","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology Monash University  Clayton Australia"},{"name":"Stem Cells and Development Program, Monash Biomedicine Discovery Institute Monash University  Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3284-9749","authenticated-orcid":false,"given":"Mohammad","family":"Asghari\u2010Jafarabadi","sequence":"additional","affiliation":[{"name":"Cabrini Research Cabrini Health  Malvern Australia"},{"name":"School of Public Health and Preventive Medicine 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 Clayton Australia"},{"name":"Stem Cells and Development Program, Monash Biomedicine Discovery Institute Monash University  Clayton Australia"},{"name":"Cabrini Monash University Department of Surgery Cabrini Hospital  Malvern Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1951-547X","authenticated-orcid":false,"given":"Rebekah\u00a0M.","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology Monash University  Clayton Australia"},{"name":"Stem Cells and Development Program, Monash Biomedicine Discovery Institute Monash University  Clayton Australia"},{"name":"Cabrini Monash University Department of Surgery Cabrini Hospital  Malvern Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul\u00a0J.","family":"McMurrick","sequence":"additional","affiliation":[{"name":"Cabrini Monash University Department of Surgery Cabrini Hospital  Malvern 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