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Despite representing only 3% of new cancer cases, it is projected to become the second leading cause of cancer\u2010related deaths by 2030. Currently, early diagnosis remains a significant challenge, and survival rates remain poor due to the lack of effective screening tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a comprehensive literature review to explore the most recent advances in PDAC detection, focusing on novel biomarkers, liquid biopsies, artificial intelligence (AI)\u2013enhanced imaging, and non\u2010invasive surveillance strategies. We examined the role of circulating tumor DNA (ctDNA), microRNAs, and volatile organic compounds (VOCs) as diagnostic tools, alongside the integration of advanced imaging modalities like MRI, EUS, and MRCP in high\u2010risk individuals, including those with hereditary cancer syndromes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Emerging technologies, such as AI\u2010driven imaging and liquid biopsy, have shown promising improvements in detecting PDAC at earlier, potentially resectable stages. Surveillance strategies for high\u2010risk populations, including BRCA1\/2 mutation carriers and individuals with Lynch syndrome, have demonstrated increased detection of Stage I PDAC, offering a significant opportunity for curative intervention. AI and machine learning techniques are also enhancing the sensitivity and specificity of imaging, providing a new frontier in early\u2010stage diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The integration of molecular diagnostics, advanced imaging technologies, and AI may enable a paradigm shift in PDAC detection, transitioning from late to early\u2010stage diagnosis and potentially improving survival rates. However, further clinical validation and standardization of these technologies are essential to ensure their widespread clinical adoption. The future of PDAC detection lies in a multimodal, personalized approach, optimizing diagnostic accuracy and early intervention for high\u2010risk individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70281","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T04:01:13Z","timestamp":1771214473000},"page":"895-913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Toward Timely Diagnosis of Pancreatic Cancer: Revolutionizing Early Detection Through Genomics, Artificial Intelligence, and Noninvasive Biomarkers"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9663-4959","authenticated-orcid":false,"given":"Muhammad\u00a0Masroor","family":"Hussain","sequence":"first","affiliation":[{"name":"Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital Sichuan University  Chengdu China"},{"name":"Research Center for Biliary Diseases, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Qammar","sequence":"additional","affiliation":[{"name":"Sheikh Zayed Medical College\/Hospital  Rahim Yar Khan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital Sichuan University  Chengdu China"},{"name":"Research Center for Biliary Diseases, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao\u2010Qiang","family":"Zhai","sequence":"additional","affiliation":[{"name":"Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital Sichuan University  Chengdu China"},{"name":"Research Center for Biliary Diseases, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2755-2887","authenticated-orcid":false,"given":"Fu\u2010yu","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital Sichuan University  Chengdu China"},{"name":"Research Center for Biliary Diseases, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010jie","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital Sichuan University  Chengdu China"},{"name":"Research Center for Biliary Diseases, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_25_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31825ffbfb"},{"key":"e_1_2_25_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"e_1_2_25_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(18)30316-8"},{"key":"e_1_2_25_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.02.014"},{"key":"e_1_2_25_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-13-12"},{"key":"e_1_2_25_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"issue":"6","key":"e_1_2_25_8_1","article-title":"Advances in the Early Diagnosis of Pancreatic Ductal Adenocarcinoma and Premalignant Pancreatic Lesions","volume":"11","author":"Yamada R.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_25_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2018.09.012"},{"key":"e_1_2_25_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20006"},{"issue":"2","key":"e_1_2_25_11_1","first-page":"70","article-title":"The Role of Surgery for Pancreatic Cancer: A 12\u2010Year Review of Patient Outcome","volume":"79","author":"Badger S. 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