{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:25:46Z","timestamp":1790717146375,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Intestinal adverse effects induced by immune checkpoint inhibitors (ICIs) during oncology treatment reduce patients' quality of life and limit the clinical application of ICIs. To elucidate the pathogenesis of ICI\u2010associated colitis and explore potential therapeutic strategies, we established a mouse model of PD\u20101 inhibitor\u2010induced colitis. Utilizing a comprehensive suite of experimental techniques, including RNA sequencing, single\u2010cell RNA sequencing data analysis, hematoxylin\u2013eosin (HE) staining, immunohistochemistry (IHC), enzyme\u2010linked immunosorbent assay (ELISA), Western blot (WB), small\u2010animal in\u00a0vivo imaging, and tumor cell function assays, we demonstrated that IL\u20106 is highly upregulated in the colitis mouse model. Moreover, the IL\u20106\u2010JAK2\u2010STAT3 signaling pathway was significantly enriched, and the expression of proteins involved in this pathway was reduced following the addition of tocilizumab. This led to a decrease in colonic inflammation and a slowing of tumor growth. Therefore, we conclude that tocilizumab may attenuate PD\u20101 inhibitor\u2010associated colonic inflammation and coinhibit tumor growth by targeting the IL\u20106\u2010JAK2\u2010STAT3 pathway, providing new insights for clinical treatment.<\/jats:p>","DOI":"10.1111\/jgh.70293","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:59:04Z","timestamp":1777445944000},"page":"1494-1506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tocilizumab Mitigates Immune Checkpoint Inhibitor\u2013Induced Colitis and Inhibits Tumor Growth by Targeting the IL\u20106\u2010JAK2\u2010STAT3 Signaling Pathway"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-8255","authenticated-orcid":false,"given":"Yanxin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiotherapy The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University\/Hunan Cancer Hospital  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University\/Hunan Cancer Hospital  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University\/Hunan Cancer Hospital  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingrong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University\/Hunan Cancer Hospital  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University\/Hunan Cancer Hospital  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University\/Hunan Cancer Hospital  Changsha Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Hunan Jiahui Genetics Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2022-0615"},{"issue":"8","key":"e_1_2_10_4_1","first-page":"358","article-title":"Diagnosis and Management of Immune Checkpoint Inhibitor Colitis","volume":"17","author":"Hashash J. 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