{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:56:25Z","timestamp":1781812585203,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endoscopic submucosal dissection (ESD) is limited by unstable visualization, insufficient traction, and the ergonomic burden of manual endoscope manipulation, particularly in the colorectum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We developed EndoDreams, a flexible robotic ESD assistant integrating master\u2013slave control for both dual\u2010arm instrumentation and endoscope guidance (insertion, withdrawal, and rotation). Master\u2013slave responsiveness was quantified in benchtop latency and repeatability tests. In\u00a0vivo feasibility was evaluated in a porcine, lesion\u2010level randomized study (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924; 12 gastric, 12 colorectal), with each lesion resected under robotic assistance using standardized ESD protocols.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bench testing showed minimal master\u2013slave latency (within 300\u2009ms). In\u00a0vivo, with comparable lesion sizes (approximately 2.3\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      ), EndoDreams significantly increased dissection efficiency, with shorter dissection time and higher standardized dissection speed, which improved submucosal exposure in both gastric lesions and colorectal lesions. EndoDreams. Safety outcomes suggested a potential benefit for EndoDreams platform, particularly in the colorectal lesions (lower muscular injury and perforation), and in which operator workload (NASA\u2010TLX) was reduced as well.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The EndoDreams system addresses major limitations in conventional ESD by enabling endoscope delivery and precise, dual\u2010arm tissue handling under a master\u2013slave control framework. The combined benchtop and in\u00a0vivo validations confirm its feasibility and clinical safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70297","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:41:37Z","timestamp":1773186097000},"page":"1507-1515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Master\u2013Slave Controlled Flexible Robotic System for\u00a0Endoscopic Submucosal Dissection: Integrated Endoscope Guidance and Dual\u2010Arm Manipulation (With\u00a0Video)"],"prefix":"10.1111","volume":"41","author":[{"given":"Jianxiao","family":"Chen","sequence":"first","affiliation":[{"name":"Robo Medical Technology Co, Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-2651","authenticated-orcid":false,"given":"Miko\u00a0Lin","family":"Lv","sequence":"additional","affiliation":[{"name":"Robo Medical Technology Co, Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Robo Medical Technology Co, Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Shen","sequence":"additional","affiliation":[{"name":"Robo Medical Technology Co, Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Ke","sequence":"additional","affiliation":[{"name":"Robo Medical Technology Co, Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[{"name":"Robo Medical Technology Co, Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Xu","sequence":"additional","affiliation":[{"name":"Robo Medical Technology Co, Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunxing","family":"Su","sequence":"additional","affiliation":[{"name":"Robo Medical Technology Co, Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Yang","sequence":"additional","affiliation":[{"name":"Robo Medical Technology Co, Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-8771","authenticated-orcid":false,"given":"Xiuli","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.068"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13883"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"60","article-title":"Endoscopic Submucosal Tunnel Dissection for Large Esophageal Neoplastic Lesions","volume":"45","author":"Linghu E.","year":"2013","journal-title":"Endoscopy"},{"key":"e_1_2_10_5_1","first-page":"1","article-title":"Training Program Using a Traction Device Improves Trainees' Learning Curve of Colorectal Endoscopic Submucosal Dissection","volume":"36","author":"Mitsuyoshi Y.","year":"2021","journal-title":"Surgical Endoscopy"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-825838"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.04.192"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1352-3850"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12400-4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2211-x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2699-5861"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11701-025-02686-7"},{"issue":"02","key":"e_1_2_10_13_1","article-title":"Endoscopic Submucosal Dissection (ESD) Versus Transanal Minimally Invasive Surgery (TAMIS) in Early Rectal Neoplasia. 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