{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:52:34Z","timestamp":1775641954359,"version":"3.50.1"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["18191921"],"award-info":[{"award-number":["18191921"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      We determined the outcomes of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      (HP) eradication on fracture risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study of patients who had received clarithromycin\u2010based triple therapy for HP infection or undergone upper endoscopy with no HP infection found (HP negative) between 2003 and 2012 in Hong Kong. Patients were divided into three groups: (i) HP\u2010negative, (ii) successful HP eradication, and (iii) delayed\/failed HP eradication, and were observed till fracture development, death, or end of study. Propensity score (PS) adjustment was performed to account for \u2265\u200920 covariates (age, sex, comorbidities, and time\u2010varying medication use). Following the establishment of PS\u2010matched cohorts, the hazard ratio (HR) of fracture with HP eradication outcome was calculated by a multivariable Cox model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 322\u2009180 eligible patients, 250\u2009978 (77.9%) were HP\u2010negative, 61\u2009892 (19.2%) had successful HP eradication, and 9310 (2.9%) delayed\/failed eradication. During a median follow\u2010up of 11.5\u2009years (IQR: 8.8\u201314.2), 16\u2009935 (5.3%) developed fracture (vertebra: 1825; hip: 8338; humerus: 2147; forearm: 4080; carpal\/wrist: 545). Compared with the HP\u2010negative group, the successful HP eradication group did not have a higher fracture risk (HR: 1.02; 95% CI: 0.89\u20131.16). However, a higher fracture risk was observed in the delayed\/failed HP eradication group (HR: 1.37; 95% CI: 1.21\u20131.56). Among delayed\/failed HP eradication patients with and without prior history of gastric ulcer, the HR was 2.21 (95% CI: 1.10\u20134.45) and 1.35 (95% CI: 1.19\u20131.54), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When compared with HP\u2010negative individuals, only HP\u2010positive patients with delayed\/failed HP eradication had a higher fracture risk, particularly in those with a prior history of gastric ulcer. These results may suggest a potential protective association of successful HP eradication and subsequent fracture risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70310","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:01:15Z","timestamp":1773032475000},"page":"1232-1243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Successful Versus Delayed\/Failed\n                    <scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    Eradication Therapy on Subsequent Fracture Risk: a Population\u2010Based Cohort Study"],"prefix":"10.1111","volume":"41","author":[{"given":"Jing\u00a0Tong","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Clinical Medicine, The University of Hong Kong Queen Mary Hospital  Hong Kong, 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