{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:44:53Z","timestamp":1780494293194,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Patients with hepatitis B virus\u2010related acute\u2010on\u2010chronic liver failure (HBV\u2010ACLF) have a high short\u2010term mortality. This study aims to explore the predictive value of KAT8 in ACLF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, a carbon tetrachloride\/lipopolysaccharide\/D\u2010galactosamine\u2010induced ACLF mouse model was established. In parallel, PBMCs were collected from a prospective cohort comprising patients with HBV\u2010ACLF, chronic hepatitis B (CHB), HBV\u2010related liver cirrhosis (LC), and healthy individuals (HI) to investigate the association between KAT8 expression and ACLF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In liver tissues from the ACLF animal model, the expression of KAT8 was significantly decreased. Meanwhile, in human PBMCs, KAT8 expression levels were significantly lower in the HBV\u2010ACLF group than in HI, but higher than those in patients with CHB and HBV\u2010related LC. Furthermore, survivors exhibited significantly higher KAT8 levels than non\u2010survivors (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). KAT8 shows potential prognostic value for 28\u2010day and 90\u2010day mortality in HBV\u2010ACLF, with AUROC values of 0.90 and 0.97, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>KAT8 may serve as a valuable biomarker for the prognosis prediction of patients with HBV\u2010ACLF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70313","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:53:20Z","timestamp":1773003200000},"page":"1244-1253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["KAT8: A Promising Biomarker for the Prognosis of Hepatitis B Virus\u2010Related Acute\u2010on\u2010Chronic Liver Failure"],"prefix":"10.1111","volume":"41","author":[{"given":"Xiaolin","family":"Wang","sequence":"first","affiliation":[{"name":"Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing Youan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9026-5204","authenticated-orcid":false,"given":"Wenling","family":"Wang","sequence":"additional","affiliation":[{"name":"Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing Youan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Yang","sequence":"additional","affiliation":[{"name":"Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing Youan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Lu","sequence":"additional","affiliation":[{"name":"Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing Youan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Fourth Department of Liver Disease, Beijing Key Laboratory of Liver Regeneration and Artificial Liver Transformation Research, Beijing Youan Hospital Capital Medical University  Beijing 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