{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T19:15:28Z","timestamp":1782501328025,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016147","name":"Korean Association for the Study of the Liver","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) are guideline\u2010endorsed first\u2010line options for antiviral\u2010naive chronic hepatitis B (CHB). We compared their associations with hepatocellular carcinoma (HCC) occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We assembled a multicenter cohort of 1364 treatment\u2010naive CHB patients initiating either TAF (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009322) or TDF (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091042) between 2012 and 2019. Confounding was addressed using 1:2 propensity score (PS) matching and inverse probability of treatment weighting (IPTW).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The PS\u2010matched analytic set comprised 966 patients (TAF 322; TDF 644). Over 60\u2009months, nine HCC events occurred (two TAF and seven TDF events). Crude incidence rates were 0.17 and 0.27 per 100 person\u2010years for TAF and TDF, respectively. Five\u2010year cumulative risks were 0.6% (TAF) versus 1.0% (TDF). In multivariable models, TAF remained protective (adjusted hazard ratio [aHR]: 0.29, 95% confidence interval [CI]: 0.13\u20130.66;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Findings were directionally consistent across subgroups, with the strongest associations observed among patients without diabetes, those who were hepatitis B e antigen\u2013positive, and those with baseline HBV DNA in the 5\u20138 log10 IU\/mL range. In IPTW analyses, TAF was likewise associated with lower HCC risk (aHR: 0.31, 95% CI: 0.14\u20130.68;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with TDF, TAF use was associated with an approximately 71% reduction in HCC hazard. Larger cohorts with longer follow\u2010up are warranted to corroborate these observations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70326","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:04:28Z","timestamp":1773032668000},"page":"1583-1589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tenofovir Alafenamide vs. Tenofovir Disoproxil Fumarate in Lowering the Risk of HCC Development in Patients With CHB"],"prefix":"10.1111","volume":"41","author":[{"given":"Seong\u00a0Hee","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-2754","authenticated-orcid":false,"given":"Hyung\u00a0Joon","family":"Yim","sequence":"additional","affiliation":[{"name":"Department 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