{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:54:38Z","timestamp":1781812478041,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High antibiotic resistance and limited tetracycline accessibility severely restrict the clinical application of classic bismuth quadruple therapy (BQT), creating an urgent demand for alternative regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic search was conducted in PubMed, Embase, Cochrane Library, and Web of Science up to June 3, 2025, for trials comparing\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication rates and adverse events between semisynthetic tetracycline\u2010containing quadruple therapies and non\u2010semisynthetic tetracycline controls. Statistical analysis was performed using RevMan 5.4.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This meta\u2010analysis included 11 randomized controlled trials (RCTs) and two retrospective studies (3667 participants). Semisynthetic tetracycline\u2010containing regimens yielded significantly higher Hp eradication rates (per\u2010protocol [PP] analysis: 91.8% vs. 85.6%; OR\u2009=\u20091.47, 95% CI: 1.08\u20132.00;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and fewer adverse events (32% vs. 39.2%; OR\u2009=\u20090.73, 95% CI: 0.56\u20130.94;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Minocycline\u2010containing regimens were associated with a higher incidence of dizziness\/headache (18.9% vs. 10.5%; OR\u2009=\u20092.22, 95% CI: 1.74\u20132.84;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001). Subgroup PP analysis showed doxycycline\u2010containing regimens outperformed controls (82.6% vs. 71.8%; OR\u2009=\u20091.56, 95% CI: 1.03\u20132.35;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), and a 14\u2010day course improved eradication rates (92.3% vs. 88.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Semisynthetic tetracycline\u2010containing regimens exhibit favorable efficacy and safety for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication, representing promising alternatives to traditional tetracyclines in clinical practice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70348","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:49:16Z","timestamp":1773906556000},"page":"1403-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of Quadruple Therapy With Semisynthetic Tetracycline for\n                    <scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    Eradication: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3542-7113","authenticated-orcid":false,"given":"Qi\u2010Qi","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Department of Gastroenterology &amp; Hepatology, Xijing Hospital The Fourth Military Medical University  Xi'an China"},{"name":"Postgraduate Department Xi'an Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Department of Gastroenterology &amp; Hepatology, Xijing Hospital The Fourth Military Medical University  Xi'an China"},{"name":"Department of Gastroenterology Pingdingshan Medical District, 989 Hospital of PLA Joint Logistics Support Force  Pingdingshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Jing","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Department of Gastroenterology &amp; Hepatology, Xijing Hospital The Fourth Military 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