{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T05:50:02Z","timestamp":1793857802988,"version":"4.6.1"},"reference-count":75,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) is a major public health challenge, with Asia now the global epicenter. In response, population\u2010based screening has become a cornerstone of CRC control in the region. This review provides a comprehensive analysis of the established national screening programs in Japan, South Korea, and Taiwan, comparing strategies, effectiveness, and quality assurance (QA) frameworks to identify key challenges and future directions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed program governance, screening strategies, effectiveness data, QA frameworks, and cost\u2010effectiveness, as well as emerging policies addressing issues such as young\u2010onset CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The population\u2010based screening programs in all three countries primarily utilize the fecal immunochemical test (FIT) and have demonstrably reduced CRC mortality. While FIT remains the backbone of these programs, colonoscopy is being increasingly explored as a potential primary strategy in select contexts, but its capacity and manpower remain a concern for its use in population screening. QA is central to maintaining effectiveness. Cost\u2010effectiveness analyses generally support both FIT\u2010based and colonoscopy\u2010based approaches, with risk\u2010adapted strategies appearing to be the most efficient. Recent evidence highlights the importance of earlier initiation of screening in Asia, reflecting the rising incidence of young\u2010onset CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Population\u2010based FIT\u2010based screening is a highly effective public health strategy in East Asia. The future of CRC screening is a personalized paradigm, adapting policies such as lowering the screening age based on regional evidence and implementing risk stratification to build upon current successes and further mitigate the region's disease burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70352","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:26:38Z","timestamp":1774851998000},"page":"1415-1426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Population Colorectal Cancer Screening in Asia: Insights From Established Programs"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-2614","authenticated-orcid":false,"given":"Wen\u2010Feng","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masau","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Endoscopy Division\/Cancer Screening Center National Cancer Center Hospital  Tokyo Japan"},{"name":"Division of Screening Technology National Cancer Center Institute for Cancer Control  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongkuk","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology Yonsei University Wonju Severance Christian Hospital  Wonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Toho University Omori Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2786-8056","authenticated-orcid":false,"given":"Han\u2010Mo","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0189-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000543921"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16910"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/or.2023.10576"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00726-3"},{"key":"e_1_2_8_7_1","unstructured":"Cancer Statistics \u201cCancer Information Service NCC \u201d Japan https:\/\/ganjoho.jp\/en\/index.html."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81877-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000133"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2023.101850"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.06.043"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-017-0587-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16244278"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322545"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy182"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-10-199705150-00014"},{"key":"e_1_2_8_17_1","article-title":"Guaiac\u2010Based Faecal Occult Blood Tests Versus Faecal Immunochemical Tests for Colorectal Cancer Screening in Average\u2010Risk Individuals","volume":"6","author":"Grobbee E. 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