{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:28:15Z","timestamp":1792099695277,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>The incidence of colorectal cancer (CRC) keeps rising throughout Asia but validated models for predicting advanced colorectal neoplasia (ACN) in Thai populations are absent locally. Limited colonoscopy capacity highlights the need for precolonoscopy risk stratification. This study developed and validated a Thai\u2010specific prediction model of ACN in asymptomatic adults, aged \u2265\u200940\u2009years, by utilizing routine clinical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective cross\u2010sectional study was conducted at Pattani Hospital, Thailand (2020\u20132024). Adults aged \u2265\u200940\u2009years undergoing colonoscopy were included and assigned to derivation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009715) and temporal validation within a single center (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009659) cohorts. Seven clinical predictors\u2014age, sex, body mass index, diabetes mellitus, smoking, alcohol use, and family history of CRC\u2014were modeled using multivariable fractional\u2013polynomial interaction (MFPI) logistic regression. Model performance was assessed using area under the receiver\u2010operating characteristic curve (AUC), calibration\u2010in\u2010the\u2010large (CITL), calibration slope, Brier score, and decision\u2010curve analysis (DCA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1374 participants, 192 (13.9%) had ACN. The model achieved AUCs of 0.76 (95% CI 0.72\u20130.81) in the derivation cohort and 0.67 (95% CI 0.60\u20130.76) in the validation cohort, with calibration slope 0.76 and CITL 0.002. Bootstrap shrinkage was 0.94. DCA demonstrated consistent net benefit across risk thresholds of 7%\u201365%. Using a 12% risk cutoff, one ACN was detected for every three colonoscopies, reducing colonoscopy volume by 48.4%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Thai\u2010specific MFPI model demonstrates good calibration, temporal validation, and clinically meaningful utility. Its application may optimize colonoscopy allocation and strengthen precision precolonoscopy risk stratification in resource\u2010limited settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70360","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:03:47Z","timestamp":1774587827000},"page":"1556-1563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk\u2010Based Colonoscopy Prioritization Model for Advanced Colorectal Neoplasia: Development and Validation Study"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7746-2631","authenticated-orcid":false,"given":"Chote","family":"Wongkanong","sequence":"first","affiliation":[{"name":"Department of Surgery Pattani Hospital  Pattani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thawee","family":"Ratanachu\u2010ek","sequence":"additional","affiliation":[{"name":"Surgical Endoscopy Unit, Department of Surgery, Rajavithi Hospital, Department of Medical Services, Ministry of Public Health  Mueang Nonthaburi Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusta","family":"Salaeh","sequence":"additional","affiliation":[{"name":"Department of Surgery Pattani Hospital  Pattani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanton","family":"Patumanond","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Clinical Statistics Unit, Faculty of Medicine Naresuan University  Phitsanulok 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