{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:39:30Z","timestamp":1792003170375,"version":"4.4.0"},"reference-count":142,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100022956","name":"Journal of Gastroenterology and Hepatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ulcerative colitis (UC) and Crohn's disease (CD) are increasingly prevalent in the Asia Pacific region, necessitating updated, region\u2010specific guidance on advanced therapies. Targeted small molecule agents, such as filgotinib, tofacitinib, upadacitinib, etrasimod, and ozanimod; and the IL\u201023 p19 inhibitors (guselkumab, mirikizumab, risankizumab) are the newest advanced therapies in our armamentarium for the treatment of IBD. The aim of the Asia\u2010Pacific consensus statements is to provide context\u2010specific recommendations integrating real\u2010world evidence specific to our region. The Asian\u2010Pacific Association of Gastroenterology (APAGE) Committee on Inflammatory Bowel Disease, with the participation of Asian Education Network in Inflammatory Bowel Disease (AEN\u2010IBD), convened a forum of 34 IBD experts from 12 countries to develop consensus guidelines on the best practices on the use of these new advanced therapies using the modified Delphi method. IL\u201023 p19 inhibitors have shown good efficacy in biologic\u2010na\u00efve and experienced patients in both UC and CD, with clinical and endoscopic superiority over ustekinumab and an excellent safety profile. JAK inhibitors (tofacitinib and filgotinib) are efficacious in UC, and upadacitinib is efficacious in both UC and CD. They have a rapid time to response, and emerging data on acute severe UC appears promising. However, careful screening and monitoring is needed for known side effects, and prophylactic vaccination for herpes zoster should be considered. S1P modulators (ozanimod, etrasimod) are efficacious in UC with a favorable side effect profile.<\/jats:p>","DOI":"10.1111\/jgh.70379","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:06:33Z","timestamp":1778583993000},"page":"2006-2029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Asian Pacific Association of Gastroenterology (APAGE) Clinical Practice Guidelines on the Use of Small Molecules and IL\u201023 p19 Inhibitors in Ulcerative Colitis and Crohn's Disease"],"prefix":"10.1111","volume":"41","author":[{"given":"Choon\u00a0Jin","family":"Ooi","sequence":"first","affiliation":[{"name":"Duke\u2010NUS Medical School  Outram Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoon\u00a0Lin","family":"Ling","sequence":"additional","affiliation":[{"name":"Duke\u2010NUS Medical School  Outram 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