{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:52:41Z","timestamp":1781794361687,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Although reusable colonoscopes remain the clinical gold standard, persistent microbial biofilms compromise reprocessing efficacy and increase cross\u2010contamination risk. This study evaluated a novel single\u2010use colonoscope compared to a conventional device across key clinical and patient\u2010centered outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a single\u2010blind randomized trial, 100 patients (aged 18\u201380\u2009years) undergoing conscious sedation colonoscopy were assigned (1:1) to a single\u2010use colonoscope (Endofresh XZING\u2010C200B) or a conventional colonoscope (Olympus CF\u2010H260). Primary endpoints included patient comfort (assessed via real\u2010time grip strength dynamometry), therapeutic endoscopic mucosal resection (EMR) efficacy, adenoma detection rate (ADR), adenomas per colonoscopy (APC), and cecal intubation time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Groups were demographically balanced. No significant differences were observed in patient comfort (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05), EMR outcomes (100% en bloc resection; median procedure times: 11.32\u2009\u00b1\u20094.55 vs. 11.57\u2009\u00b1\u20097.95\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.899), diagnostic performance (ADRs: 56% vs. 60%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.685; APCs median: 1.0 vs. 1.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.349), or cecal intubation time (7.47\u2009\u00b1\u20095.81 vs. 6.13\u2009\u00b1\u20094.06\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.185). One sigmoid colon cancer was detected per group. The single\u2010use device showed inferior image quality and far\u2010field brightness (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this exploratory randomized trial, the novel single\u2010use colonoscope demonstrated clinical efficacy and safety profiles comparable to the conventional system. These preliminary findings support its potential for integration into routine screening, pending confirmation in larger noninferiority studies.<\/jats:p>\n                    <jats:p>Chinese Clinical Trial Registry: ChiCTR2400082142.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70387","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T01:35:37Z","timestamp":1776735337000},"page":"1751-1759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Randomized Controlled Trial Evaluating the Safety, Efficacy, and Patient Comfort of a Single\u2010Use Electronic Colonoscope"],"prefix":"10.1111","volume":"41","author":[{"given":"Yuan","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Endoscopy Center Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Center Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Center Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Center Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Center Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangjiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Center Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Center Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5450-0535","authenticated-orcid":false,"given":"Long","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Center Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100370"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2024.526"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt354"},{"issue":"8","key":"e_1_2_12_5_1","first-page":"10","article-title":"Endoscope Contagion Raises Questions About FDA Oversight","volume":"45","author":"Rice S.","year":"2015","journal-title":"Modern Healthcare"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v12.i3.122"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2021.1917990"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.05.057"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.15040"},{"key":"e_1_2_12_10_1","unstructured":"Tottori University Daikin Industries LTD. 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