{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:52:59Z","timestamp":1788529979925,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Early\u2010onset colorectal cancer (EOCRC) diagnosed at before 50\u2009years of age has been increasing globally. We conducted a nationwide study to compare the associations of clinical and lifestyle characteristics with 5\u2010year survival between EOCRC and later\u2010onset colorectal cancer (LOCRC) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 92\u2009365 colorectal cancer (CRC) patients from the Taiwan Cancer Registry diagnosed between 2002 and 2015, with mortality follow\u2010up until 2020. Clinical factors included tumor and treatment characteristics. Lifestyle factors included body mass index (BMI), cigarette smoking, and alcohol consumption. Poisson regression was used to obtain risk ratios and 95% confidence intervals for 5\u2010year overall and CRC\u2010specific survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EOCRC patients had more advanced cancer staging, less right\u2010sided colon cancer, and less treatment delay of \u2265\u200930\u2009days than LOCRC patients. EOCRC also had a higher proportion of females and current alcohol or cigarette users. Female sex and treatment delay of &lt;\u200930\u2009days were significantly associated with improved 5\u2010year overall survival among LOCRC patients but not EOCRC patients. After adjusting for sex and tumor characteristics, EOCRC patients demonstrated slightly better 5\u2010year CRC\u2010specific survival than LOCRC individuals for all CRC sites combined, right\u2010sided colon, left\u2010sided colon, and rectum. Underweight BMI was associated with significantly worse survival only in LOCRC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings of distinct characteristics and prognosis between EOCRC and LOCRC patients contribute to the understanding of CRC by age at diagnosis, which may inform patient surveillance and counseling, as well as promote studies to evaluate age\u2010specific CRC screening and treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70401","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T03:35:08Z","timestamp":1777260908000},"page":"1792-1802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Five\u2010Year Survival Prognosis of Early\u2010Onset and Later\u2010Onset Colorectal Cancer by Clinical and Lifestyle Characteristics"],"prefix":"10.1111","volume":"41","author":[{"given":"Tai\u2010Chuan","family":"Kuan","sequence":"first","affiliation":[{"name":"Institute of Public Health National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Division of Colon &amp; Rectal Surgery, Department of Surgery Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Informatics National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Division of Translational Research, Department of Medical Research Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Chih","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery Sun Yat\u2010sen Cancer Center  Taipei 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