{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:39:35Z","timestamp":1787668775754,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Colorectal cancer (CRC) progression is closely associated with gut microbiota.\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Bacteroides thetaiotaomicron<\/jats:italic>\n                      <\/jats:styled-content>\n                      (B.theta), a key species in the human cecal and colonic microbiota, plays an incompletely defined role in CRC progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CRC animal models were established utilizing immunocompetent C57BL\/6 mice and immunodeficient BALB\/C nude mice. Histopathological changes were assessed by H&amp;E staining. Immune cell infiltration was evaluated by IHC. CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells and cancer cells were treated with B.theta culture supernatant. Cytokine secretion was measured by ELISA. Surface protein expression levels on CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells and cancer cell apoptosis were analyzed by flow cytometry. CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell proliferation was determined by the CFSE assay. Tumor\u2010killing activity of CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells was assessed by LDH release assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In C57BL\/6 mice, B.theta suppressed tumor development and promoted T cell infiltration. However, B.theta had no significant impact on CRC progression in BALB\/C nude mice. B.theta supernatant treatment did not affect CRC cell phenotypes, including viability, apoptosis, MHC\u2010I expression, and extracellular ATP levels. Conversely, B.theta supernatant upregulated CD69 and CD44 expression on CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells, promoted IFN\u2010\u03b3 and TNF\u2010\u03b1 secretion, enhanced proliferation, and consequently augmented their cytotoxicity against CRC cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>B.theta suppresses malignant CRC progression by modulating host immune responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70412","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:17:46Z","timestamp":1778577466000},"page":"2150-2158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>\n                      <i>Bacteroides thetaiotaomicron<\/i>\n                    <\/scp>\n                    Improves Colorectal Cancer Prognosis by Remodeling the Immune Microenvironment"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7429-9918","authenticated-orcid":false,"given":"Zesheng","family":"Shi","sequence":"first","affiliation":[{"name":"AnoRectal Surgery Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital, Fujian)  Jinjiang Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deling","family":"Zou","sequence":"additional","affiliation":[{"name":"AnoRectal Surgery Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital, Fujian)  Jinjiang Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoming","family":"Hong","sequence":"additional","affiliation":[{"name":"AnoRectal Surgery Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital, Fujian)  Jinjiang Fujian 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