{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:52:52Z","timestamp":1781794372093,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Crohn's disease (CD) is a chronic inflammatory bowel disease characterized by excessive intestinal fibrosis. We previously demonstrated that periostin is highly expressed in various fibrosis\u2010related diseases and is important in the development of fibrosis. In this study, we aimed to investigate the role of periostin in the pathogenesis of CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated periostin expression in the terminal ileum of CD patients. We examined serum periostin levels in 75 CD patients and 150 healthy controls. We applied periostin\u2010deficient (PNKO) and wild\u2010type (WT) mice to a mouse model mimicking CD induced by repeated intrarectal administration of 2,4,6\u2010trinitrobenzene sulfonic acid (TNBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Periostin was highly expressed in the stenotic areas of CD patients compared with controls, correlated with the severity of intestinal fibrosis. Serum periostin levels were significantly higher in CD patients than in healthy controls (88.5\u2009ng\/mL vs. 65.5\u2009ng\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). In the mice with TNBS\u2010induced colitis, periostin was highly expressed transmurally in the intestines, similar to CD patients. Fibrosis scores, collagen deposition, and phosphorylation of Smad3 were significantly increased in WT mice, whereas these were attenuated in PNKO mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CD patients showed significantly high expression of periostin in both tissues and serum. Taken together with its important role in the underlying mechanism of fibrosis in the TNBS\u2010treated mice, periostin is involved in the development of fibrosis in CD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70413","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:45:16Z","timestamp":1777689916000},"page":"1854-1862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Involvement of Periostin in Intestinal Fibrosis Associated With Crohn's Disease"],"prefix":"10.1111","volume":"41","author":[{"given":"Hironobu","family":"Takedomi","sequence":"first","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Sciences Saga Medical School  Saga Japan"},{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nunomura","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Sciences Saga Medical School  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nanri","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Sciences Saga Medical School  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Honda","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Sciences Saga Medical School  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Okada","sequence":"additional","affiliation":[{"name":"Division of Allergy, Department of Biomolecular Sciences Saga Medical School  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tun","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Sciences Saga Medical School  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kento","family":"Sadashima","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Akutagawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanae","family":"Tsuruoka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhisa","family":"Sakata","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon\u00a0J.","family":"Conway","sequence":"additional","affiliation":[{"name":"Herman B. 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