{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:02:34Z","timestamp":1788447754954,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>This study evaluated clinical outcomes in patients with hepatocellular carcinoma (HCC) treated with durvalumab plus tremelimumab (Dur\/Tre) in routine practice, stratified by whether they fulfilled the eligibility criteria of the phase 3 HIMALAYA trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 412 patients with unresectable HCC receiving Dur\/Tre at 30 Japanese institutions were enrolled. Of these, 92 fulfilled the HIMALAYA trial eligibility criteria (HIMALAYA group) and 320 did not (non\u2010HIMALAYA group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median progression\u2010free survival (PFS) was 5.4\u2009months in the HIMALAYA group and 3.0\u2009months in the non\u2010HIMALAYA group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). Multivariable analysis identified body mass index \u2265\u200925\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (hazard ratio [HR], 0.780; 95% confidence interval [CI], 0.612\u20130.993;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044) and portal vein invasion (HR, 1.509; 95% CI, 1.049\u20132.170;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027) as independent predictors of PFS. Median overall survival (OS) was 19.4\u2009months in the HIMALAYA group versus 15.4\u2009months in the non\u2010HIMALAYA group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). Multivariable analysis showed Eastern Cooperative Oncology Group performance status \u2265\u20091 (HR, 1.878; 95% CI, 1.253\u20132.814;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and albumin\u2013bilirubin grade \u2265\u20092 (HR, 2.032; 95% CI, 1.319\u20133.318;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) as independent determinants of OS. Any\u2010grade endocrine dysfunction occurred in 13 (14.1%) and 21 (6.6%) patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030), with grade \u2265\u20093 events in 5 (5.4%) and 2 (0.6%), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Subgroup analysis suggested that non\u2010HIMALAYA patients with ALBI grade 1 may have OS comparable to the HIMALAYA group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients fulfilling the HIMALAYA trial eligibility criteria and those who did not but had preserved hepatic function demonstrated favorable survival outcomes with Dur\/Tre.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70422","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T06:45:39Z","timestamp":1779518739000},"page":"2138-2149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes of Patients With Hepatocellular Carcinoma Treated With Durvalumab Plus Tremelimumab in Real\u2010World Clinical Practice Who Met or Did Not Meet the Inclusion Criteria for the Phase 3 HIMALAYA Trial"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7114-5464","authenticated-orcid":false,"given":"Tomomitsu","family":"Matono","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Harima Himeji General Medical Center  Himeji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-6761","authenticated-orcid":false,"given":"Toshifumi","family":"Tada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"},{"name":"Department of Internal Medicine Japanese Red Cross Society Himeji Hospital  Himeji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-0480","authenticated-orcid":false,"given":"Atsushi","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ehime Prefectural Central Hospital  Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5634-5313","authenticated-orcid":false,"given":"Masashi","family":"Hirooka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-0045","authenticated-orcid":false,"given":"Osamu","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon 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